Robert W Egan
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Explore the profile of Robert W Egan including associated specialties, affiliations and a list of published articles.
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20
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532
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Recent Articles
11.
McLeod R, Rizzo C, West Jr R, Aslanian R, McCormick K, Bryant M, et al.
J Pharmacol Exp Ther
. 2003 Mar;
305(3):1037-44.
PMID: 12649305
We present the pharmacological and pharmacokinetic profiles of a novel histamine H3 receptor antagonist, N-(3,5-dichlorophenyl)-N'-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687). The H3-receptor binding Ki values for SCH 79687 were 1.9 and 13 nM...
12.
Garlisi C, Zou J, Devito K, Tian F, Zhu F, Liu J, et al.
Biochem Biophys Res Commun
. 2003 Jan;
301(1):35-43.
PMID: 12535637
ADAM33 (a disintegrin and metalloprotease) was recently found to be a novel asthma susceptibility gene. Domain-specific antibodies were used to study its expression and processing. When the pro-domain and catalytic...
13.
Jia Y, McLeod R, Wang X, Parra L, Egan R, Hey J
Br J Pharmacol
. 2002 Nov;
137(6):831-6.
PMID: 12411414
1. Endogenous neuronal lipid mediator anandamide, which can be synthesized in the lung, is a ligand of both cannabinoid (CB) and vanilloid receptors (VR). The tussigenic effect of anandamide has...
14.
McHugh N, Vercesi H, Egan R, Hey J
Am J Physiol Endocrinol Metab
. 2002 Oct;
284(1):E70-5.
PMID: 12388153
Anesthetized Sprague-Dawley weanling rats were scanned for bone mineral density (BMD) values after 7 days of treatment to determine whether resorption/growth at the proximal tibia can be quantified by peripheral...
15.
Anthes J, Chapman R, Richard C, Eckel S, Corboz M, Hey J, et al.
Eur J Pharmacol
. 2002 Sep;
450(2):191-202.
PMID: 12206858
Experiments were performed to characterize the pharmacology of SCH 206272 [(R,R)-1'[5-[(3,5-dichlorobenzoyl)methylamino]-3-(3,4-dichlorophenyl)-4(Z)-(methoxyimino)pentyl]-N-methyl-2-oxo-[1,4'bipiperidine]-3-acetamide] as a potent and selective antagonist of tachykinin (NK) NK(1), NK(2), and NK(3) receptors. SCH 206272 inhibited binding at...
16.
Van Eerdewegh P, Little R, Dupuis J, Mastro R, Falls K, Simon J, et al.
Nature
. 2002 Jul;
418(6896):426-30.
PMID: 12110844
Asthma is a common respiratory disorder characterized by recurrent episodes of coughing, wheezing and breathlessness. Although environmental factors such as allergen exposure are risk factors in the development of asthma,...
17.
McLeod R, Bolser D, Jia Y, Parra L, Mutter J, Wang X, et al.
Pulm Pharmacol Ther
. 2002 Jul;
15(3):213-6.
PMID: 12099766
Cough is an important defensive pulmonary reflex that removes irritants, fluids or foreign materials from the airways. However, often cough is non-productive and requires suppression. Opioid mu receptor agonists, such...
18.
House A, Celly C, Hey J, Egan R, Chapman R
Pulm Pharmacol Ther
. 2002 Jul;
15(2):169-73.
PMID: 12090791
Neurokinin A (NKA) potentiates airway cholinergic neurotransmission in several species. In this study, the role of cholinergic reflexes on the bronchoconstrictor response to NKA was evaluated in non-sensitized dogs and...
19.
Billah M, Cooper N, Minnicozzi M, Warneck J, Wang P, Hey J, et al.
J Pharmacol Exp Ther
. 2002 Jun;
302(1):127-37.
PMID: 12065709
N-(3,5-Dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide (SCH 351591) has been identified as a potent (IC(50) = 58 nM) and highly selective type 4 phosphodiesterase (PDE4) inhibitor with oral bioactivity in several animal models of...
20.
Rizzo C, Yang R, Greenfeder S, Egan R, Pauwels R, Hey J
J Allergy Clin Immunol
. 2002 Mar;
109(3):404-9.
PMID: 11897983
Background: The role of IL-5-induced eosinophilia in airway hyperresponsiveness has been questioned. In addition, eosinophil-independent IL-5-induced airway hyperresponsiveness has been demonstrated in animals. Objective: In this study, IL-5 was investigated...