Robert W Curley Jr
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Explore the profile of Robert W Curley Jr including associated specialties, affiliations and a list of published articles.
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36
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623
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Recent Articles
1.
Durojaye B, Riedl K, Curley Jr R, Harrison E
J Lipid Res
. 2019 Mar;
60(6):1121-1135.
PMID: 30846527
β-Apocarotenoids are eccentric cleavage products of carotenoids formed by chemical and enzymatic oxidations. They occur in foods containing carotenoids and thus might be directly absorbed from the diet. However, there...
2.
Cooperstone J, Novotny J, Riedl K, Cichon M, Francis D, Curley Jr R, et al.
Am J Clin Nutr
. 2018 Sep;
108(4):784-792.
PMID: 30239552
Background: Nonvitamin A apocarotenoids occur in foods. Some function as retinoic acid receptor antagonists in vitro, though it is unclear if apocarotenoids are absorbed or accumulate to levels needed to...
3.
Anding A, Jones J, Newton M, Curley Jr R, Clagett-Dame M
Anticancer Res
. 2018 Aug;
38(8):4403-4416.
PMID: 30061204
Background/aim: N-(4-hydroxyphenyl)retinamide (4-HPR) is a synthetic retinoid, less toxic than the parent all-trans retinoic acid (RA). Unlike RA, 4-HPR induces apoptosis in tumor cells. Because 4-HPR can hydrolyze to liberate...
4.
Spiegler E, Kim Y, Hoyos B, Narayanasamy S, Jiang H, Savio N, et al.
Sci Rep
. 2018 Jun;
8(1):8834.
PMID: 29892071
Vitamin A deficiency is still a public health concern affecting millions of pregnant women and children. Retinoic acid, the active form of vitamin A, is critical for proper mammalian embryonic...
5.
Cavanaugh K, Narayanasamy S, Walker J, Clagett-Dame M, Curley Jr R
J Carbohydr Chem
. 2017 Jun;
35(5):249-260.
PMID: 28626297
Improvements in the synthesis of carbon-linked glucuronide/glucoside conjugates of cancer chemopreventive retinoids have been achieved starting with 2,3,4,6-tetra--benzyl-D-glucopyranose. The revised approach demonstrates better yields, eliminates the use of an expensive,...
6.
Acuna U, Curley Jr R, Fatima N, Ahmed S, Chang L, de Blanco E
Anticancer Res
. 2017 Apr;
37(4):1617-1623.
PMID: 28373422
Background/aim: The survival rate of women diagnosed with triple-negative breast-cancer (TNBC) remains low. Hence, this study aimed at the chemical and biological optimization of furanosteroid derivatives for the treatment of...
7.
Narayanasamy S, Sun J, Pavlovicz R, Eroglu A, Rush C, Sunkel B, et al.
J Lipid Res
. 2017 Mar;
58(5):1021-1029.
PMID: 28250025
Consumption of the tomato carotenoid, lycopene, has been associated with favorable health benefits. Some of lycopene's biological activity may be due to metabolites resulting from cleavage of the lycopene molecule....
8.
Harrison E, Curley Jr R
Subcell Biochem
. 2016 Nov;
81:1-19.
PMID: 27830499
Carotenoids are polyenes synthesized in plants and certain microorganisms and are pigments used by plants and animals in various physiological processes. Some of the over 600 known carotenoids are capable...
9.
Goetz H, Kopec R, Riedl K, Cooperstone J, Narayanasamy S, Curley Jr R, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2016 Jul;
1029-1030:68-71.
PMID: 27423669
Enzymatic cleavage of the nonsymmetric provitamin A carotenoid α-carotene results in one molecule of retinal (vitamin A), and one molecule of α-retinal, a biologically inactive analog of true vitamin A....
10.
Costabile B, Kim Y, Iqbal J, Zuccaro M, Wassef L, Narayanasamy S, et al.
J Biol Chem
. 2016 Jul;
291(35):18525-35.
PMID: 27402843
β-Carotene is an important source of vitamin A for the mammalian embryo, which depends on its adequate supply to achieve proper organogenesis. In mammalian tissues, β-carotene 15,15'-oxygenase (BCO1) converts β-carotene...