Robert T Sarisky
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Explore the profile of Robert T Sarisky including associated specialties, affiliations and a list of published articles.
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48
Citations
1116
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Recent Articles
1.
Ranjith-Kumar C, Lai Y, Sarisky R, Kao C
PLoS One
. 2010 Sep;
5(9):e12878.
PMID: 20877565
Background: The Innate immune system constitutes the first line of defense against pathogen infections. The Retinoic acid-inducible gene I (RIG-I) receptor recognizes triphosphorylated ssRNAs and dsRNA to initiate downstream signaling...
2.
Clayton R, Ohagen A, Nicol F, Del Vecchio A, Jonckers T, Goethals O, et al.
Antiviral Res
. 2009 Aug;
84(2):142-9.
PMID: 19699239
Selective delivery of antiretrovirals to human immunodeficiency virus (HIV) infected cells may reduce toxicities associated with long-term highly active antiretroviral therapy (HAART), may improve therapeutic compliance and delay the emergence...
3.
Shaw A, Tedesco R, Bambal R, Chai D, Concha N, Darcy M, et al.
Bioorg Med Chem Lett
. 2009 Jun;
19(15):4350-3.
PMID: 19515564
The synthesis and optimisation of HCV NS5B polymerase inhibitors with improved potency versus the existing compound 1 is described. Substitution in the benzothiadiazine portion of the molecule, furnishing improvement in...
4.
Tedesco R, Chai D, Darcy M, Dhanak D, Fitch D, Gates A, et al.
Bioorg Med Chem Lett
. 2009 Jun;
19(15):4354-8.
PMID: 19505821
Modification of the benzo rings of 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones into heteroaromatic systems was investigated to enhance physicochemical properties and potency profile of this class of inhibitors. The synthesis and biological activity of...
5.
Stowell N, Seideman J, Raymond H, Smalley K, Lamb R, Egenolf D, et al.
Respir Res
. 2009 Jun;
10:43.
PMID: 19486528
Background: The immune mechanisms associated with infection-induced disease exacerbations in asthma and COPD are not fully understood. Toll-like receptor (TLR) 3 has an important role in recognition of double-stranded viral...
6.
Murray L, Knight D, McAlonan L, Argentieri R, Joshi A, Shaheen F, et al.
Am J Respir Crit Care Med
. 2008 Oct;
178(12):1227-37.
PMID: 18849495
Rationale: Acute respiratory distress syndrome (ARDS) manifests clinically as a consequence of septic and/or traumatic injury in the lung. Oxygen therapy remains a major therapeutic intervention in ARDS, but this...
7.
Del Vecchio A, Sarisky R
Recent Pat Antiinfect Drug Discov
. 2008 Jan;
1(2):247-54.
PMID: 18221150
Human respiratory syncytial virus (HRSV) is a major respiratory viral pathogen causing moderate to severe upper and lower respiratory tract infections in all ages and across a wide range of...
8.
Duffy K, Lamb R, San Mateo L, Jordan J, Canziani G, Brigham-Burke M, et al.
Cell Immunol
. 2007 Dec;
248(2):103-14.
PMID: 18048020
Toll-like receptors are a family of pattern-recognition receptors that contribute to the innate immune response. Toll-like receptor 3 (TLR3) signals in response to foreign, endogenous and synthetic ligands including viral...
9.
Liu C, Day N, Branigan P, Gutshall L, Sarisky R, Del Vecchio A
Virol J
. 2007 Jul;
4:71.
PMID: 17623075
To elucidate the relationship between resistance to HRSV neutralizing antibodies directed against the F protein and the fusion activity of the F protein, a recombinant approach was used to generate...
10.
Lamb R, Capocasale R, Duffy K, Sarisky R, Mbow M
J Immunol
. 2007 Jun;
178(12):7833-9.
PMID: 17548621
Bone marrow-derived immunomodulatory cytokines impart a critical function in the regulation of innate immune responses and hemopoiesis. However, the source of immunomodulatory cytokines in murine bone marrow and the cellular...