Robert Sprung
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Explore the profile of Robert Sprung including associated specialties, affiliations and a list of published articles.
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21
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1713
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Recent Articles
1.
Ryan M, Portelance R, Newman G, Martinez G, Shekharan S, Wu A, et al.
bioRxiv
. 2025 Jan;
PMID: 39763866
Tyrosine phosphorylation is an important post-translational modification that regulates many biochemical signaling networks in multicellular organisms. To date, 46,000 tyrosines have been observed in human proteins, but relatively little is...
2.
Pokhrel N, Panfil A, Habib H, Seeniraj S, Joseph A, Rauch D, et al.
J Extracell Vesicles
. 2024 Oct;
13(10):e12516.
PMID: 39385703
Adult T cell leukaemia (ATL), caused by infection with human T- lymphotropic virus type 1 (HTLV-1), is often complicated by hypercalcemia and osteolytic lesions. Therefore, we studied the communication between...
3.
Djune-Yemeli L, Hertz M, Nana-Djeunga H, Rush A, Erdmann-Gilmore P, Sprung R, et al.
Front Parasitol
. 2024 Aug;
2.
PMID: 39176078
Background And Methods: Circulating antigens are often detected in individuals with heavy infections by diagnostic tests for lymphatic filariasis (LF) caused by . This is a major challenge to LF...
4.
Arthur N, Christensen K, Mannino K, Ruzinova M, Kumar A, Gruszczynska A, et al.
Clin Cancer Res
. 2024 Jun;
30(16):3622-3639.
PMID: 38848040
Purpose: Somatic missense mutations in the phosphodegron domain of the MYC gene (MYC Box I or MBI) are detected in the dominant clones of a subset of patients with acute...
5.
Pokhrel N, Panfil A, Habib H, Seeniraj S, Joseph A, Rauch D, et al.
bioRxiv
. 2024 Mar;
PMID: 38496506
Adult T cell leukemia (ATL), caused by infection with human T cell leukemia virus type 1 (HTLV-1), is often complicated by hypercalcemia and osteolytic lesions. Therefore, we studied the communication...
6.
Arthur N, Christensen K, Mannino K, Ruzinova M, Kumar A, Gruszczynska A, et al.
bioRxiv
. 2023 Nov;
PMID: 37961226
Somatic missense mutations in the phosphodegron domain of the gene ( M YC Box I) are detected in the dominant clones of a subset of acute myeloid leukemia (AML) patients,...
7.
Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a -dependent manner in mice
Parhizkar S, Gent G, Chen Y, Rensing N, Gratuze M, Strout G, et al.
Sci Transl Med
. 2023 Apr;
15(693):eade6285.
PMID: 37099634
Sleep loss is associated with cognitive decline in the aging population and is a risk factor for Alzheimer's disease (AD). Considering the crucial role of immunomodulating genes such as that...
8.
Uzoechi S, Rosa B, Singh K, Choi Y, Bracken B, Brindley P, et al.
Pathogens
. 2023 Jan;
12(1).
PMID: 36678443
The dynamic host-parasite mechanisms underlying hookworm infection establishment and maintenance in mammalian hosts remain poorly understood but are primarily mediated by hookworm's excretory/secretory products (ESPs), which have a wide spectrum...
9.
Rosa B, Curtis K, Gilmore P, Martin J, Zhang Q, Sprung R, et al.
Mol Cell Proteomics
. 2022 Nov;
22(1):100454.
PMID: 36435333
Onchocerca volvulus, the causative agent of onchocerciasis, infects over 20 million people and can cause severe dermatitis and ocular conditions including blindness. Current treatments employed in mass drug administration programs...
10.
Kramer M, Zhang Q, Sprung R, Day R, Erdmann-Gilmore P, Li Y, et al.
Blood
. 2022 Jul;
140(13):1533-1548.
PMID: 35895896
We have developed a deep-scale proteome and phosphoproteome database from 44 representative acute myeloid leukemia (AML) patients from the LAML TCGA dataset and 6 healthy bone marrow-derived controls. After confirming...