Robert S Foster
Overview
Explore the profile of Robert S Foster including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
10
Citations
31
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Burns M, Ponting D, Foster R, Thornton B, Romero N, Smith G, et al.
J Pharm Sci
. 2023 Oct;
112(12):3005-3011.
PMID: 37805074
N-Nitrosamines are a class of indirect acting mutagens, as their metabolic degradation leads to the formation of the DNA-alkylating diazonium ion. Following up on the in-silico identification of thousands of...
2.
Cayley A, Foster R, Brigo A, Muster W, Musso A, Kenyon M, et al.
Regul Toxicol Pharmacol
. 2023 Sep;
144:105490.
PMID: 37659712
Expert review of two predictions, made by complementary (quantitative) structure-activity relationship models, to an overall conclusion is a key component of using in silico tools to assess the mutagenic potential...
3.
Chilton M, Api A, Foster R, Gerberick G, Lavelle M, Macmillan D, et al.
Regul Toxicol Pharmacol
. 2022 Jun;
133:105200.
PMID: 35662638
The Dermal Sensitisation Thresholds (DST) are Thresholds of Toxicological Concern, which can be used to justify exposure-based waiving when conducting a skin sensitisation risk assessment. This study aimed to update...
4.
Cayley A, Foster R, Hill E, Kane S, Kocks G, Myden A, et al.
ALTEX
. 2022 May;
40(1):34–52.
PMID: 35575642
The traditional paradigm for safety assessment of chemicals for their carcinogenic potential to humans relies heavily on a battery of well-established genotoxicity tests, usually followed up by long-term, high-dose rodent...
5.
Ponting D, Burns M, Foster R, Hemingway R, Kocks G, Macmillan D, et al.
Methods Mol Biol
. 2022 Feb;
2425:435-478.
PMID: 35188642
Lhasa Limited have had a role in the in silico prediction of drug and other chemical toxicity for over 30 years. This role has always been multifaceted, both as a...
6.
Foster R, Fowkes A, Cayley A, Thresher A, Werner A, Barber C, et al.
Genes Environ
. 2020 Sep;
42:27.
PMID: 32983286
The use of in silico predictions for the assessment of bacterial mutagenicity under the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) M7 guideline is...
7.
Comas-Barcelo J, Foster R, Fiser B, Gomez-Bengoa E, Harrity J
Chemistry
. 2015 Jan;
21(8):3257-63.
PMID: 25557473
Cu salts have been found to promote the cycloaddition reaction of sydnones and terminal alkynes, providing significant reduction in reaction times. Specifically, the use of Cu(OTf)2 is found to provide...
8.
Foster R, Adams H, Jakobi H, Harrity J
J Org Chem
. 2013 Apr;
78(8):4049-64.
PMID: 23548035
We report the synthesis and some structural studies of 4-trifluoromethyl, 4-difluoromethyl-, and 4-monofluoromethylsydnones. All but the latter compounds are stable and represent effective precursors to a range of pyrazoles after...
9.
Foster R, Jakobi H, Harrity J
Org Lett
. 2012 Sep;
14(18):4858-61.
PMID: 22934538
Two synthetic approaches to 4-trifluoromethylsydnones, a novel class of these mesoionic reagents, are reported. These compounds undergo regioselective alkyne cycloaddition reactions, thereby providing a general approach to 5-trifluoromethylpyrazoles. This method...
10.
Foster R, Huang J, Vivat J, Browne D, Harrity J
Org Biomol Chem
. 2009 Sep;
7(19):4052-6.
PMID: 19763310
A concise synthesis of three members of the withasomnine family of natural products is reported. The synthesis features a regioselective sydnone-alkynylboronate cycloaddition followed by Suzuki cross coupling and silyl group...