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Robert Planque

Explore the profile of Robert Planque including associated specialties, affiliations and a list of published articles. Areas
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Articles 24
Citations 400
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Recent Articles
1.
Teusink B, Planque R, Bruggeman F
Nat Metab . 2025 Jan; 7(1):8-10. PMID: 39762389
No abstract available.
2.
Bruggeman F, Remeijer M, Droste M, Salinas L, Wortel M, Planque R, et al.
Biosystems . 2024 Nov; :105067. PMID: 39492480
Since its conception some fifty years ago, metabolic control analysis (MCA) aims to understand how cells control their metabolism by adjusting the activity of their enzymes. Here we extend its...
3.
Berkvens A, Salinas L, Remeijer M, Planque R, Teusink B, Bruggeman F
Essays Biochem . 2024 Apr; 68(1):41-51. PMID: 38662439
The expression of metabolic proteins is controlled by genetic circuits, matching metabolic demands and changing environmental conditions. Ideally, this regulation brings about a competitive level of metabolic fitness. Understanding how...
4.
Meng Z, Capel R, Bose S, Bosch E, de Jong S, Planque R, et al.
Biophys J . 2023 Jun; 122(15):3044-3059. PMID: 37329137
Spontaneous calcium release by ryanodine receptors (RyRs) due to intracellular calcium overload results in delayed afterdepolarizations, closely associated with life-threatening arrhythmias. In this regard, inhibiting lysosomal calcium release by two-pore...
5.
Diekmann O, Othmer H, Planque R, Bootsma M
Proc Natl Acad Sci U S A . 2021 Sep; 118(39). PMID: 34561307
The COVID-19 pandemic has led to numerous mathematical models for the spread of infection, the majority of which are large compartmental models that implicitly constrain the generation-time distribution. On the...
6.
Clement T, Baalhuis E, Teusink B, Bruggeman F, Planque R, de Groot D
Patterns (N Y) . 2021 Jan; 2(1):100177. PMID: 33511367
The metabolic capabilities of cells determine their biotechnological potential, fitness in ecosystems, pathogenic threat levels, and function in multicellular organisms. Their comprehensive experimental characterization is generally not feasible, particularly for...
7.
Bruggeman F, Planque R, Molenaar D, Teusink B
FEMS Microbiol Rev . 2020 Oct; 44(6):821-844. PMID: 33099619
Why do evolutionarily distinct microorganisms display similar physiological behaviours? Why are transitions from high-ATP yield to low(er)-ATP yield metabolisms so widespread across species? Why is fast growth generally accompanied with...
8.
de Groot D, Hulshof J, Teusink B, Bruggeman F, Planque R
PLoS Comput Biol . 2020 Jan; 16(1):e1007559. PMID: 31986156
In this paper we try to describe all possible molecular states (phenotypes) for a cell that fabricates itself at a constant rate, given its enzyme kinetics and the stoichiometry of...
9.
de Groot D, Lischke J, Muolo R, Planque R, Bruggeman F, Teusink B
Cell Mol Life Sci . 2019 Nov; 77(3):441-453. PMID: 31758233
Living cells can express different metabolic pathways that support growth. The criteria that determine which pathways are selected in which environment remain unclear. One recurrent selection is overflow metabolism: the...
10.
Diekmann O, Planque R
J Math Biol . 2019 Apr; 80(1-2):283-301. PMID: 31030298
The aim of this short note is to give a simple explanation for the remarkable periodicity of Magicicada species, which appear as adults only every 13 or 17 years, depending...