Josephus Hulshof
Overview
Explore the profile of Josephus Hulshof including associated specialties, affiliations and a list of published articles.
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7
Citations
194
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Recent Articles
1.
de Groot D, Hulshof J, Teusink B, Bruggeman F, Planque R
PLoS Comput Biol
. 2020 Jan;
16(1):e1007559.
PMID: 31986156
In this paper we try to describe all possible molecular states (phenotypes) for a cell that fabricates itself at a constant rate, given its enzyme kinetics and the stoichiometry of...
2.
Planque R, Hulshof J, Teusink B, Hendriks J, Bruggeman F
PLoS Comput Biol
. 2018 Sep;
14(9):e1006412.
PMID: 30235207
One of the marvels of biology is the phenotypic plasticity of microorganisms. It allows them to maintain high growth rates across conditions. Studies suggest that cells can express metabolic enzymes...
3.
Overal G, Teusink B, Bruggeman F, Hulshof J, Planque R
Math Biosci
. 2018 Mar;
299:117-126.
PMID: 29550298
Yeast glycolysis has been the focus of research for decades, yet a number of dynamical aspects of yeast glycolysis remain poorly understood at present. If nutrients are scarce, yeast will...
4.
Heerden J, Wortel M, Bruggeman F, Heijnen J, Bollen Y, Planque R, et al.
Microb Cell
. 2017 Mar;
1(3):103-106.
PMID: 28357229
In the model eukaryote , it has long been known that a functional trehalose pathway is indispensable for transitions to high glucose conditions. Upon addition of glucose, cells with a...
5.
Planque R, Bruggeman F, Teusink B, Hulshof J
Math Biosci
. 2014 Jun;
255:33-42.
PMID: 24956444
Unlabelled: Glycolysis is the central pathway in energy metabolism in the majority of organisms. In a recent paper, van Heerden et al. showed experimentally and computationally that glycolysis can exist...
6.
Wortel M, Peters H, Hulshof J, Teusink B, Bruggeman F
FEBS J
. 2014 Jan;
281(6):1547-55.
PMID: 24460934
Specific product formation rates and cellular growth rates are important maximization targets in biotechnology and microbial evolution. Maximization of a specific rate (i.e. a rate expressed per unit biomass amount)...
7.
van Heerden J, Wortel M, Bruggeman F, Heijnen J, Bollen Y, Planque R, et al.
Science
. 2014 Jan;
343(6174):1245114.
PMID: 24436182
Cells need to adapt to dynamic environments. Yeast that fail to cope with dynamic changes in the abundance of glucose can undergo growth arrest. We show that this failure is...