Robert P Fagan
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Explore the profile of Robert P Fagan including associated specialties, affiliations and a list of published articles.
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34
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1549
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Recent Articles
1.
Buddle J, Thompson L, Williams A, Wright R, Durham W, Turner C, et al.
PLoS Biol
. 2024 Aug;
22(8):e3002741.
PMID: 39146240
Clostridioides difficile is an important human pathogen, for which there are very limited treatment options, primarily the glycopeptide antibiotic vancomycin. In recent years, vancomycin resistance has emerged as a serious...
2.
Galley N, Greetham D, Alaman-Zarate M, Williamson M, Evans C, Spittal W, et al.
J Biol Chem
. 2023 Dec;
300(1):105529.
PMID: 38043796
Clostridioides difficile is the leading cause of antibiotic-associated diarrhea worldwide with significant morbidity and mortality. This organism is naturally resistant to several beta-lactam antibiotics that inhibit the polymerization of peptidoglycan,...
3.
Phothichaisri W, Phetruen T, Chankhamhaengdecha S, Janvilisri T, Ounjai P, Fagan R, et al.
Methods Mol Biol
. 2023 Nov;
2738:245-262.
PMID: 37966604
Physical interactions between bacteria and phages provide valuable insights into the mechanisms of phage infection and may provide information on the use of phages as a therapeutic approach. In this...
4.
Ormsby M, Vaz F, Kirk J, Barwinska-Sendra A, Hallam J, Lanzoni-Mangutchi P, et al.
PLoS Pathog
. 2023 Jun;
19(6):e1011015.
PMID: 37384772
Clostridioides difficile is responsible for substantial morbidity and mortality in antibiotically-treated, hospitalised, elderly patients, in which toxin production correlates with diarrhoeal disease. While the function of these toxins has been...
5.
Royer A, Umansky A, Allen M, Garneau J, Ospina-Bedoya M, Kirk J, et al.
Microbiol Spectr
. 2023 Feb;
:e0389422.
PMID: 36790200
Therapeutic bacteriophages (phages) are being considered as alternatives in the fight against Clostridioides difficile infections. To be efficient, phages should have a wide host range, buthe lack of knowledge about...
6.
Buddle J, Fagan R
Virulence
. 2022 Nov;
14(1):2150452.
PMID: 36419222
is the most common cause of nosocomial antibiotic-associated diarrhea, and is responsible for a spectrum of diseases characterized by high levels of recurrence, morbidity, and mortality. Treatment is complex, since...
7.
Phothichaisri W, Chankhamhaengdecha S, Janvilisri T, Nuadthaisong J, Phetruen T, Fagan R, et al.
Microbiol Spectr
. 2022 Apr;
10(2):e0236121.
PMID: 35377223
Endolysin is a phage-encoded cell-wall hydrolase which degrades the peptidoglycan layer of the bacterial cell wall. The enzyme is often expressed at the late stage of the phage lytic cycle...
8.
Lanzoni-Mangutchi P, Banerji O, Wilson J, Barwinska-Sendra A, Kirk J, Vaz F, et al.
Nat Commun
. 2022 Feb;
13(1):970.
PMID: 35217634
Many bacteria and archaea possess a two-dimensional protein array, or S-layer, that covers the cell surface and plays crucial roles in cell physiology. Here, we report the crystal structure of...
9.
Fuchs M, Lamm-Schmidt V, Sulzer J, Ponath F, Jenniches L, Kirk J, et al.
Proc Natl Acad Sci U S A
. 2021 Jun;
118(25).
PMID: 34131082
The gram-positive human pathogen has emerged as the leading cause of antibiotic-associated diarrhea. However, little is known about the bacterium's transcriptome architecture and mechanisms of posttranscriptional control. Here, we have...
10.
Alabdali Y, Oatley P, Kirk J, Fagan R
Anaerobe
. 2021 May;
70:102379.
PMID: 33940167
Background: Sporulation is a complex cell differentiation programme shared by many members of the Firmicutes, the end result of which is a highly resistant, metabolically inert spore that can survive...