Robert Layfield
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Explore the profile of Robert Layfield including associated specialties, affiliations and a list of published articles.
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6719
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Recent Articles
1.
Milborne B, Arjuna A, Islam M, Arafat A, Layfield R, Thompson A, et al.
ACS Omega
. 2025 Jan;
9(52):50933-50944.
PMID: 39758667
This study presents the development and characterization of high yttrium-content phosphate-based glass-ceramic microspheres for potential applications in bone cancer radiotherapy treatment. The microspheres produced via flame spheroidization, followed by sieving,...
2.
Brennan A, Oldham N, Layfield R, Scott D
Methods Mol Biol
. 2024 Aug;
2845:237-246.
PMID: 39115671
Establishing the hATG8 binding selectivity of AIM (autophagy-interacting motif) sequences found within autophagy system proteins provides insights into their biological roles, and in the case of disease-associated AIM mutations, potential...
3.
White K, Bailey H, Shaw B, Geiszler P, Mesquita-Ribeiro R, Scott D, et al.
Front Cell Neurosci
. 2024 Jun;
18:1414142.
PMID: 38915876
Extracellular vesicles (EVs) are secreted by all cells in the CNS, including neurons and astrocytes. EVs are lipid membrane enclosed particles loaded with various bioactive cargoes reflecting the dynamic activities...
4.
Olszewski J, Hall R, Kootker L, Oldham N, Layfield R, Shaw B, et al.
Sci Rep
. 2023 Sep;
13(1):14666.
PMID: 37673940
Skeletal remains discovered in Simon's Town, South Africa, were hypothesised as being associated with a former Dutch East India Company (VOC) hospital. We report a novel combined osteological and biochemical...
5.
Griffiths R, Smith F, Li D, Wyatt J, Rogers D, Long J, et al.
Chemistry
. 2022 Dec;
29(16):e202202503.
PMID: 36534955
The site-selective modification of peptides and proteins facilitates the preparation of targeted therapeutic agents and tools to interrogate biochemical pathways. Among the numerous bioconjugation techniques developed to install groups of...
6.
Ducker C, Ratnam M, Shaw P, Layfield R
Protein Expr Purif
. 2022 Dec;
203:106216.
PMID: 36528218
Post-translational modifications (PTMs) are important for protein folding and activity, and the ability to recreate physiologically relevant PTM profiles on recombinantly-expressed proteins is vital for meaningful functional analysis. The ETS...
7.
Milborne B, Murrell L, Cardillo-Zallo I, Titman J, Briggs L, Scotchford C, et al.
Bioengineering (Basel)
. 2022 Nov;
9(11).
PMID: 36354522
Phosphate-based glasses (PBGs) are promising materials for bone repair and regeneration as they can be formulated to be compositionally similar to the inorganic components of bone. Alterations to the PBG...
8.
Brennan A, Layfield R, Long J, Williams H, Oldham N, Scott D, et al.
J Biol Chem
. 2021 Dec;
298(2):101514.
PMID: 34929165
Recognition of human autophagy-related 8 (hATG8) proteins by autophagy receptors represents a critical step within this cellular quality control system. Autophagy impairment is known to be a pathogenic mechanism in...
9.
Griffiths R, Smith F, Long J, Scott D, Williams H, Oldham N, et al.
Angew Chem Int Ed Engl
. 2021 Oct;
61(2):e202110223.
PMID: 34713958
Post-translational modifications (PTMs) enhance the repertoire of protein function and mediate or influence the activity of many cellular processes. The preparation of site-specifically and homogeneously modified proteins, to apply as...
10.
Dongdem J, Dawson S, Layfield R
Proteomics
. 2021 Jun;
21(15):e2000234.
PMID: 34086420
Additional complexity in the post-translational modification of proteins by ubiquitin is achieved by ubiquitin phosphorylation, for example within PINK1-parkin mediated mitophagy. We performed a preliminary proteomic analysis to identify proteins...