Robert J Clubb
Overview
Explore the profile of Robert J Clubb including associated specialties, affiliations and a list of published articles.
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9
Citations
271
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Recent Articles
1.
Luan H, Bailey T, Clubb R, Mohapatra B, Bhat A, Chakraborty S, et al.
Cancers (Basel)
. 2021 Aug;
13(16).
PMID: 34439093
Overexpression of the epidermal growth factor receptor (EGFR) family member ErbB2 (HER2) drives oncogenesis in up to 25% of invasive breast cancers. ErbB2 expression at the cell surface is required...
2.
Luan H, Mohapatra B, Bielecki T, Mushtaq I, Mirza S, Jennings T, et al.
Cancer Res
. 2018 Mar;
78(10):2524-2535.
PMID: 29510992
CHIP/STUB1 ubiquitin ligase is a negative co-chaperone for HSP90/HSC70, and its expression is reduced or lost in several cancers, including breast cancer. Using an extensive and well-annotated breast cancer tissue...
3.
Bailey T, Luan H, Clubb R, Naramura M, Band V, Raja S, et al.
J Carcinog
. 2011 Dec;
10:28.
PMID: 22190870
The Human Epidermal Growth Factor Receptor 2 (Her2, ErbB2 or Neu) is overexpressed in about 20 - 25% of breast cancers and is causally linked to oncogenesis, providing opportunities for...
4.
Raja S, Clubb R, Ortega-Cava C, Williams S, Bailey T, Duan L, et al.
Cancer Biol Ther
. 2010 Nov;
11(2):263-76.
PMID: 21088503
The receptor tyrosine kinase ErbB2 is overexpressed in up to a third of breast cancers, allowing targeted therapy with ErbB2-directed humanized antibodies such as Trastuzumab. Concurrent targeting of ErbB2 stability...
5.
Duan L, Raja S, Chen G, Virmani S, Williams S, Clubb R, et al.
J Biol Chem
. 2010 Oct;
286(1):620-33.
PMID: 20940296
The E3 ubiquitin ligase Casitas B lymphoma protein (Cbl) controls the ubiquitin-dependent degradation of EGF receptor (EGFR), but its role in regulating downstream signaling elements with which it associates and...
6.
Tu C, Ortega-Cava C, Winograd P, Stanton M, Reddi A, Dodge I, et al.
Proc Natl Acad Sci U S A
. 2010 Sep;
107(37):16107-12.
PMID: 20805499
Active Src localization at focal adhesions (FAs) is essential for cell migration. How this pool is linked mechanistically to the large pool of Src at late endosomes (LEs)/lysosomes (LY) is...
7.
Chung B, Raja S, Clubb R, Tu C, George M, Band V, et al.
BMC Cell Biol
. 2009 Dec;
10:84.
PMID: 19948031
Background: Epidermal growth factor receptor (EGFR) controls a wide range of cellular processes, and altered EGFR signaling contributes to human cancer. EGFR kinase domain mutants found in non-small cell lung...
8.
Duan L, Chen G, Virmani S, Ying G, Raja S, Chung B, et al.
J Biol Chem
. 2009 Oct;
285(2):1555-68.
PMID: 19826000
Non-malignant mammary epithelial cells (MECs) undergo acinar morphogenesis in three-dimensional Matrigel culture, a trait that is lost upon oncogenic transformation. Rho GTPases are thought to play important roles in regulating...
9.
Raja S, Clubb R, Bhattacharyya M, Dimri M, Cheng H, Pan W, et al.
Cancer Biol Ther
. 2008 Sep;
7(10):1630-40.
PMID: 18769124
ErbB2 (or Her2/Neu) overexpression in breast cancer signifies poorer prognosis, yet it has provided an avenue for targeted therapy as demonstrated by the success of the humanized monoclonal antibody Trastuzumab...