Srikumar M Raja
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Explore the profile of Srikumar M Raja including associated specialties, affiliations and a list of published articles.
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27
Citations
933
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Recent Articles
1.
Luan H, Bailey T, Clubb R, Mohapatra B, Bhat A, Chakraborty S, et al.
Cancers (Basel)
. 2021 Aug;
13(16).
PMID: 34439093
Overexpression of the epidermal growth factor receptor (EGFR) family member ErbB2 (HER2) drives oncogenesis in up to 25% of invasive breast cancers. ErbB2 expression at the cell surface is required...
2.
Raja S, Desale S, Mohapatra B, Luan H, Soni K, Zhang J, et al.
Oncotarget
. 2016 Feb;
7(9):10522-35.
PMID: 26859680
Targeted delivery of anticancer drugs to tumor cells using monoclonal antibodies against oncogenic cell surface receptors is an emerging therapeutic strategy. These strategies include drugs directly conjugated to monoclonal antibodies...
3.
Desale S, Raja S, Kim J, Mohapatra B, Soni K, Luan H, et al.
J Control Release
. 2015 Feb;
208:59-66.
PMID: 25660204
ErbB2-driven breast cancers constitute 20-25% of the cases diagnosed within the USA. The humanized anti-ErbB2 monoclonal antibody, Trastuzumab (Herceptin™; Genentech), with chemotherapy is the current standard of treatment. Novel agents...
4.
Bailey T, Luan H, Tom E, Bielecki T, Mohapatra B, Ahmad G, et al.
J Biol Chem
. 2014 Sep;
289(44):30443-30458.
PMID: 25225290
ErbB2 overexpression drives oncogenesis in 20-30% cases of breast cancer. Oncogenic potential of ErbB2 is linked to inefficient endocytic traffic into lysosomes and preferential recycling. However, regulation of ErbB2 recycling...
5.
Arnst J, Davies C, Raja S, Das C, Natarajan A
Anal Biochem
. 2013 Jun;
440(1):71-7.
PMID: 23747283
Deubiquitinases (DUBs) play an important role in regulating the ubiquitin landscape of proteins. The DUB AMSH (associated molecule with the SH3 domain of STAM) has been shown to be involved...
6.
Helikar T, Kochi N, Kowal B, Dimri M, Naramura M, Raja S, et al.
PLoS One
. 2013 May;
8(4):e61757.
PMID: 23637902
The non-receptor tyrosine kinase Src and receptor tyrosine kinase epidermal growth factor receptor (EGFR/ErbB1) have been established as collaborators in cellular signaling and their combined dysregulation plays key roles in...
7.
Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases
Mohapatra B, Ahmad G, Nadeau S, Zutshi N, An W, Scheffe S, et al.
Biochim Biophys Acta
. 2012 Oct;
1833(1):122-39.
PMID: 23085373
Protein tyrosine kinases (PTKs) coordinate a broad spectrum of cellular responses to extracellular stimuli and cell-cell interactions during development, tissue homeostasis, and responses to environmental challenges. Thus, an understanding of...
8.
Ortega-Cava C, Raja S, Laiq Z, Bailey T, Luan H, Mohapatra B, et al.
J Carcinog
. 2011 Dec;
10:29.
PMID: 22190871
Background: Well over a quarter of human breast cancers are ErbB2-driven and constitute a distinct subtype with substantially poorer prognosis. Yet, there are substantial gaps in our understanding of how...
9.
Bailey T, Luan H, Clubb R, Naramura M, Band V, Raja S, et al.
J Carcinog
. 2011 Dec;
10:28.
PMID: 22190870
The Human Epidermal Growth Factor Receptor 2 (Her2, ErbB2 or Neu) is overexpressed in about 20 - 25% of breast cancers and is causally linked to oncogenesis, providing opportunities for...
10.
Tu C, Ahmad G, Mohapatra B, Bhattacharyya S, Ortega-Cava C, Chung B, et al.
Bioarchitecture
. 2011 Aug;
1(1):45-48.
PMID: 21866262
ESCRT pathway proteins play a key role in sorting ubiquitinated membrane receptors towards lysosomes providing an important mechanism for attenuating cell surface receptor signaling. However, recent studies point to a...