Robert H Silverman
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Explore the profile of Robert H Silverman including associated specialties, affiliations and a list of published articles.
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143
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7824
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Recent Articles
1.
Kirby C, Islam N, Wier E, Alphonse M, Sweren E, Wang G, et al.
J Clin Invest
. 2025 Feb;
PMID: 39903537
Mammalian injury responses are predominantly characterized by fibrosis and scarring rather than functional regeneration. This limited regenerative capacity in mammals could reflect a loss of pro-regeneration programs or active suppression...
2.
Yang K, Dong B, Asthana A, Silverman R, Yan N
EMBO J
. 2024 Aug;
43(18):3876-3894.
PMID: 39112803
The OAS-RNase L pathway is one of the oldest innate RNA sensing pathways that leads to interferon (IFN) signaling and cell death. OAS recognizes viral RNA and then activates RNase...
3.
Babu Chinnam N, Thapar R, Arvai A, Sarker A, Soll J, Paul T, et al.
J Biol Chem
. 2024 May;
300(6):107368.
PMID: 38750793
Activating signal co-integrator complex 1 (ASCC1) acts with ASCC-ALKBH3 complex in alkylation damage responses. ASCC1 uniquely combines two evolutionarily ancient domains: nucleotide-binding K-Homology (KH) (associated with regulating splicing, transcriptional, and...
4.
Otter C, Bracci N, Parenti N, Ye C, Asthana A, Blomqvist E, et al.
Proc Natl Acad Sci U S A
. 2024 Apr;
121(15):e2320194121.
PMID: 38568967
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has caused millions of deaths since its emergence in 2019. Innate immune antagonism by lethal CoVs such as SARS-CoV-2 is crucial for optimal replication...
5.
Xi J, Snieckute G, Martinez J, Arendrup F, Asthana A, Gaughan C, et al.
Cell Rep
. 2024 Mar;
43(4):113998.
PMID: 38551960
RNase L is an endoribonuclease of higher vertebrates that functions in antiviral innate immunity. Interferons induce oligoadenylate synthetase enzymes that sense double-stranded RNA of viral origin leading to the synthesis...
6.
Otter C, Bracci N, Parenti N, Ye C, Tan L, Asthana A, et al.
bioRxiv
. 2023 Nov;
PMID: 38014074
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has caused millions of deaths since emerging in 2019. Innate immune antagonism by lethal CoVs such as SARS-CoV-2 is crucial for optimal replication and...
7.
Xi J, Snieckute G, Asthana A, Gaughan C, Bekker-Jensen S, Silverman R
bioRxiv
. 2023 Oct;
PMID: 37873202
RNase L is a regulated endoribonuclease in higher vertebrates that functions in antiviral innate immunity. Interferons induce OAS enzymes that sense double-stranded RNA of viral origin leading to synthesis of...
8.
Asthana A, Corona A, Shin W, Kwak M, Gaughan C, Tramontano E, et al.
Viruses
. 2023 Jul;
15(7).
PMID: 37515225
Viral replication often depends on RNA maturation and degradation processes catalyzed by viral ribonucleases, which are therefore candidate targets for antiviral drugs. Here, we synthesized and studied the antiviral properties...
9.
Yim H, Chakrabarti A, Kessler S, Morimoto H, Wang D, Sooraj D, et al.
Front Immunol
. 2023 Mar;
14:1106737.
PMID: 36875104
Here we investigate the function of the innate immune molecule protein kinase R (PKR) in intestinal inflammation. To model a colitogenic role of PKR, we determine the physiological response to...
10.
Lee D, Le Pen J, Yatim A, Dong B, Aquino Y, Ogishi M, et al.
Science
. 2022 Dec;
379(6632):eabo3627.
PMID: 36538032
Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of , , or in five unrelated children with...