Robert H Costa
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Explore the profile of Robert H Costa including associated specialties, affiliations and a list of published articles.
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56
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Recent Articles
11.
Brezillon N, Lambert-Blot M, Morosan S, Couton D, Mitchell C, Kremsdorf D, et al.
Mol Ther
. 2007 Jun;
15(9):1710-5.
PMID: 17565348
Orthotopic liver transplantation is limited by the shortage of liver donors, leading to elderly patients being enrolled as donors with increasing frequency. Alternative strategies such as cell therapy are therefore...
12.
Yoshida Y, Wang I, Yoder H, Davidson N, Costa R
Gastroenterology
. 2007 Apr;
132(4):1420-31.
PMID: 17408638
Background & Aims: In this study, we used Forkhead Box m1b (Foxm1b) transgenic mice and conditional Foxm1 knock-out mice to examine the role of Foxm1 in colon cancer development and...
13.
Ramakrishna S, Kim I, Petrovic V, Malin D, Wang I, Kalin T, et al.
Dev Dyn
. 2007 Mar;
236(4):1000-13.
PMID: 17366632
The Forkhead Box m1 (Foxm1) transcription factor is expressed in cardiomyocytes and cardiac endothelial cells during heart development. In this study, we used a novel Foxm1 -/- mouse line to...
14.
Functional polymorphism of the Anpep gene increases promoter activity in the Dahl salt-resistant rat
Kotlo K, Hughes D, Herrera V, Ruiz-Opazo N, Costa R, Brooks Robey R, et al.
Hypertension
. 2007 Jan;
49(3):467-72.
PMID: 17242304
We have reported that aminopeptidase N/CD13, which metabolizes angiotensin III to angiotensin IV, exhibits greater renal tubular expression in the Dahl salt-resistant (SR/Jr) rat than its salt-sensitive (SS/Jr) counterpart. In...
15.
Gusarova G, Wang I, Major M, Kalinichenko V, Ackerson T, Petrovic V, et al.
J Clin Invest
. 2006 Dec;
117(1):99-111.
PMID: 17173139
The forkhead box m1 (Foxm1) transcription factor is essential for initiation of carcinogen-induced liver tumors; however, whether FoxM1 constitutes a therapeutic target for liver cancer treatment remains unknown. In this...
16.
Tan Y, Raychaudhuri P, Costa R
Mol Cell Biol
. 2006 Nov;
27(3):1007-16.
PMID: 17101782
The forkhead box M1 (FoxM1) transcription factor regulates expression of cell cycle genes essential for DNA replication and mitosis during organ repair and cancer progression. Here, we demonstrate that FoxM1-deficient...
17.
Radhakrishnan S, Bhat U, Hughes D, Wang I, Costa R, Gartel A
Cancer Res
. 2006 Oct;
66(19):9731-5.
PMID: 17018632
The oncogenic transcription factor forkhead box M1 (FoxM1) is overexpressed in a number of different carcinomas, whereas its expression is turned off in terminally differentiated cells. For this reason, FoxM1...
18.
Zhao Y, Gao X, Zhao Y, Mirza M, Frey R, Kalinichenko V, et al.
J Clin Invest
. 2006 Sep;
116(9):2333-43.
PMID: 16955137
Recovery of endothelial integrity after vascular injury is vital for endothelial barrier function and vascular homeostasis. However, little is known about the molecular mechanisms of endothelial barrier repair following injury....
19.
Tan Y, Yoshida Y, Hughes D, Costa R
Gastroenterology
. 2006 Apr;
130(4):1283-300.
PMID: 16618419
Background & Aims: The hepatocyte nuclear factor 6 (HNF6 or ONECUT-1) protein is a cell-type specific transcription factor that regulates expression of hepatocyte-specific genes. Using hepatocytes for chromatin immunoprecipitation (ChIP)...
20.
Zhang H, Ackermann A, Gusarova G, Lowe D, Feng X, Kopsombut U, et al.
Mol Endocrinol
. 2006 Mar;
20(8):1853-66.
PMID: 16556734
The FoxM1 transcription factor is highly expressed in proliferating cells and activates several cell cycle genes, although its requirement appears to be limited to certain tissue types. Embryonic hepatoblast-specific inactivation...