Eric Haugen
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Explore the profile of Eric Haugen including associated specialties, affiliations and a list of published articles.
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44
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9982
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Recent Articles
1.
Breeze C, Haugen E, Gutierrez-Arcelus M, Yao X, Teschendorff A, Beck S, et al.
Genome Biol
. 2024 Jan;
25(1):3.
PMID: 38167104
The majority of disease-associated variants identified through genome-wide association studies are located outside of protein-coding regions. Prioritizing candidate regulatory variants and gene targets to identify potential biological mechanisms for further...
2.
Paredes M, Lunn S, Famulare M, Frisbie L, Painter I, Burstein R, et al.
Clin Infect Dis
. 2022 Apr;
75(1):e536-e544.
PMID: 35412591
Background: The coronavirus disease 2019 (COVID-19) pandemic is dominated by variant viruses; the resulting impact on disease severity remains unclear. Using a retrospective cohort study, we assessed the hospitalization risk...
3.
Brandstetter K, Zulske T, Ragoczy T, Horl D, Guirao-Ortiz M, Steinek C, et al.
Biophys J
. 2022 Feb;
121(6):977-990.
PMID: 35150617
Methodological advances in conformation capture techniques have fundamentally changed our understanding of chromatin architecture. However, the nanoscale organization of chromatin and its cell-to-cell variance are less studied. Analyzing genome-wide data...
4.
Breeze C, Haugen E, Reynolds A, Teschendorff A, Dongen J, Lan Q, et al.
Genome Biol
. 2022 Jan;
23(1):13.
PMID: 34996498
Background: Genome-wide association study (GWAS) single nucleotide polymorphisms (SNPs) are known to preferentially co-locate to active regulatory elements in tissues and cell types relevant to disease aetiology. Further characterisation of...
5.
Paredes M, Lunn S, Famulare M, Frisbie L, Painter I, Burstein R, et al.
medRxiv
. 2021 Nov;
PMID: 34729567
Background: The COVID-19 pandemic is dominated by variant viruses; the resulting impact on disease severity remains unclear. Using a retrospective cohort study, we assessed the hospitalization risk following infection with...
6.
Scutelnic V, Tsuru S, Papai M, Yang Z, Epshtein M, Xue T, et al.
Nat Commun
. 2021 Aug;
12(1):5003.
PMID: 34408141
Electronic relaxation in organic chromophores often proceeds via states not directly accessible by photoexcitation. We report on the photoinduced dynamics of pyrazine that involves such states, excited by a 267 ...
7.
Vierstra J, Lazar J, Sandstrom R, Halow J, Lee K, Bates D, et al.
Nature
. 2020 Jul;
583(7818):729-736.
PMID: 32728250
Combinatorial binding of transcription factors to regulatory DNA underpins gene regulation in all organisms. Genetic variation in regulatory regions has been connected with diseases and diverse phenotypic traits, but it...
8.
Meuleman W, Muratov A, Rynes E, Halow J, Lee K, Bates D, et al.
Nature
. 2020 Jul;
584(7820):244-251.
PMID: 32728217
DNase I hypersensitive sites (DHSs) are generic markers of regulatory DNA and contain genetic variations associated with diseases and phenotypic traits. We created high-resolution maps of DHSs from 733 human...
9.
Stergachis A, Debo B, Haugen E, Churchman L, Stamatoyannopoulos J
Science
. 2020 Jun;
368(6498):1449-1454.
PMID: 32587015
Gene regulation is chiefly determined at the level of individual linear chromatin molecules, yet our current understanding of cis-regulatory architectures derives from fragmented sampling of large numbers of disparate molecules....
10.
Siebenthall K, Miller C, Vierstra J, Mathieu J, Tretiakova M, Reynolds A, et al.
EBioMedicine
. 2019 Mar;
41:427-442.
PMID: 30827930
Background: Transcriptional dysregulation drives cancer formation but the underlying mechanisms are still poorly understood. Renal cell carcinoma (RCC) is the most common malignant kidney tumor which canonically activates the hypoxia-inducible...