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Robert E Oswald

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Articles 48
Citations 660
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Recent Articles
1.
Coombs S, Banjade S, Kriksunov K, Clemente N, Zhao J, Wang C, et al.
Biochemistry . 2020 Nov; 59(48):4517-4522. PMID: 33249825
An effect of (+)MK-801 (dizocilpine), an inhibitor of the glutamate/NMDA and nicotinic acetylcholine receptors, on the Aβ[1-42] and Aβ[1-40] peptides is described and compared to that of memantine. Memantine has...
2.
Bamberger M, Nell M, Ahmed A, Santoro R, Ingraffea A, Kennedy R, et al.
Environ Sci Process Impacts . 2019 May; 21(6):988-998. PMID: 31093631
The contamination of surface water and ground water by human activities, such as fossil fuel extraction and agriculture, can be difficult to assess due to incomplete knowledge of the chemicals...
3.
Yuan C, Shi E, Srinivasan J, Ptak C, Oswald R, Nowak L
ACS Med Chem Lett . 2019 Mar; 10(3):237-242. PMID: 30891119
Postsynaptic AMPA/glutamate receptors, essential for neuronal excitability, are important targets for anticonvulsant therapy. This single channel study of the selective noncompetitive AMPA receptor antagonist, perampanel, was performed on homotetrameric GluA3...
4.
Shi E, Yuan C, Sipple M, Srinivasan J, Ptak C, Oswald R, et al.
J Gen Physiol . 2019 Jan; 151(2):156-173. PMID: 30622133
Glutamate is released from presynaptic nerve terminals in the central nervous system (CNS) and spreads excitation by binding to and activating postsynaptic iGluRs. Of the potential glutamate targets, tetrameric AMPA...
5.
Ptak C, Akif M, Hsieh C, Devarajan A, He P, Xu Y, et al.
Biotechnol Bioeng . 2018 Nov; 116(2):260-271. PMID: 30418677
Recombinant antigens exhibit targeted protectiveproperties and offer important opportunities in the development of therapeutic technologies. Biophysical and structural methods have become important tools for the rational design and engineering of...
6.
Goffin E, Drapier T, Larsen A, Geubelle P, Ptak C, Laulumaa S, et al.
J Med Chem . 2017 Dec; 61(1):251-264. PMID: 29256599
We report here the synthesis of 7-phenoxy-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides and their evaluation as AMPA receptor positive allosteric modulators (AMPApams). The impact of substitution on the phenoxy ring and on the...
7.
Hsieh C, Ptak C, Tseng A, de Souza Suguiura I, McDonough S, Sritrakul T, et al.
Elife . 2017 Dec; 6. PMID: 29210669
Pathogens rely on proteins embedded on their surface to perform tasks essential for host infection. These obligatory structures exposed to the host immune system provide important targets for rational vaccine...
8.
Oswald R
Biophys J . 2017 Nov; 113(10):2131-2132. PMID: 29102038
No abstract available.
9.
Bamberger M, Oswald R
J Environ Sci Health A Tox Hazard Subst Environ Eng . 2015 Mar; 50(5):447-59. PMID: 25734821
Public health concerns related to the expansion of unconventional oil and gas drilling have sparked intense debate. In 2012, we published case reports of animals and humans affected by nearby...
10.
Ptak C, Hsieh C, Lin Y, Maltsev A, Raman R, Sharma Y, et al.
Biochemistry . 2014 Jul; 53(32):5249-60. PMID: 25068811
A number of surface proteins specific to pathogenic strains of Leptospira have been identified. The Lig protein family has shown promise as a marker in typing leptospiral isolates for pathogenesis...