Robert E Oswald
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Explore the profile of Robert E Oswald including associated specialties, affiliations and a list of published articles.
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48
Citations
660
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Recent Articles
11.
Martinez M, Ahmed A, Loh A, Oswald R
Biochemistry
. 2014 May;
53(23):3790-5.
PMID: 24850223
Understanding the thermodynamics of binding of a lead compound to a receptor can provide valuable information for drug design. The binding of compounds, particularly partial agonists, to subtypes of the...
12.
Jenkins M, Wells G, Bachman J, Snyder J, Jenkins A, Huganir R, et al.
Mol Pharmacol
. 2014 Jan;
85(4):618-29.
PMID: 24452473
Three residues within the AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor subunit GluA1 C terminus (Ser818, Ser831, Thr840) can be phosphorylated by Ca(2+)/phospholipid-dependent protein kinase (PKC). Here, we show that PKC phosphorylation of...
13.
Ptak C, Hsieh C, Weiland G, Oswald R
ACS Chem Biol
. 2013 Oct;
9(1):128-33.
PMID: 24152170
Protein dimerization provides a mechanism for the modulation of cellular signaling events. In α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors, the rapidly desensitizing, activated state has been correlated with a weakly dimeric, glutamate-binding...
14.
Ahmed A, Ptak C, Fenwick M, Hsieh C, Weiland G, Oswald R
J Biol Chem
. 2013 Aug;
288(38):27658-27666.
PMID: 23940029
The majority of excitatory neurotransmission in the CNS is mediated by tetrameric AMPA receptors. Channel activation begins with a series of interactions with an agonist that binds to the cleft...
15.
Raman R, Ptak C, Hsieh C, Oswald R, Chang Y, Sharma Y
Biochemistry
. 2013 Jun;
52(27):4589-91.
PMID: 23800025
Many host-parasite interactions are mediated via surface-exposed proteins containing bacterial immunoglobulin-like (Big) domains. Here, we utilize the spectral properties of a conserved Trp to provide evidence that, along with a...
16.
17.
Ahmed A, Hamada M, Shinada T, Ohfune Y, Weerasinghe L, Garner P, et al.
J Biol Chem
. 2012 Oct;
287(49):41007-13.
PMID: 23076153
Glutamate receptors mediate the majority of excitatory synaptic transmission in the central nervous system, and excessive stimulation of these receptors is involved in a variety of neurological disorders and neuronal...
18.
Holley S, Ahmed A, Srinivasan J, Murthy S, Weiland G, Oswald R, et al.
Biochemistry
. 2012 Apr;
51(19):4015-27.
PMID: 22512472
Ligand-gated ion channels undergo conformational changes that transfer the energy of agonist binding to channel opening. Within ionotropic glutamate receptor (iGluR) subunits, this process is initiated in their bilobate ligand...
19.
Bamberger M, Oswald R
New Solut
. 2012 Mar;
22(1):51-77.
PMID: 22446060
Environmental concerns surrounding drilling for gas are intense due to expansion of shale gas drilling operations. Controversy surrounding the impact of drilling on air and water quality has pitted industry...
20.
Gahl R, Oswald R, Scheraga H
Biochemistry
. 2011 Dec;
51(1):521-32.
PMID: 22142378
In the oxidative folding of onconase, the stabilization of intermediates early in the folding process gives rise to efficient formation of its biologically active form. To identify the residues responsible...