Robert E London
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Explore the profile of Robert E London including associated specialties, affiliations and a list of published articles.
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105
Citations
1868
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Recent Articles
1.
London R
Drug Metab Rev
. 2024 Jan;
56(1):80-96.
PMID: 38230664
Two aminosalicylate isomers have been found to possess useful pharmacological behavior: -aminosalicylate (PAS, 4AS) is an anti-tubercular agent that targets , and 5-aminosalicylate (5AS, mesalamine, mesalazine) is used in the...
2.
Kirby T, Gabel S, DeRose E, Perera L, Krahn J, Pedersen L, et al.
Biomolecules
. 2023 Nov;
13(11).
PMID: 38002285
Formation of active HIV-1 reverse transcriptase (RT) proceeds via a structural maturation process that involves subdomain rearrangements and formation of an asymmetric p66/p66' homodimer. These studies were undertaken to evaluate...
3.
Klemm B, Singh D, Smith C, Hsu A, Dillard L, Krahn J, et al.
Proc Natl Acad Sci U S A
. 2022 Sep;
119(37):e2123092119.
PMID: 36067314
Levels of the cellular dNTPs, the direct precursors for DNA synthesis, are important for DNA replication fidelity, cell cycle control, and resistance against viruses. encodes a dGTPase (2'-deoxyguanosine-5'-triphosphate [dGTP] triphosphohydrolase...
4.
London R
DNA Repair (Amst)
. 2022 Jan;
110:103263.
PMID: 35026705
DNA repair scaffolds XRCC1 and XRCC4 utilize a phosphopeptide FHA domain binding motif (FBM) of the form Y-x-x-pS-pT-D-E that supports recruitment of three identified FHA domain-containing DNA repair proteins: polynucleotide...
5.
Collins B, Kerns S, Aillon K, Mueller G, Rider C, DeRose E, et al.
Anal Bioanal Chem
. 2021 Oct;
413(30):7627-7629.
PMID: 34689227
No abstract available.
6.
Collins B, Kerns S, Aillon K, Mueller G, Rider C, DeRose E, et al.
Anal Bioanal Chem
. 2021 Aug;
413(25):6449-6450.
PMID: 34402966
No abstract available.
7.
Kim K, Kirby T, Perera L, London R
Sci Rep
. 2021 Apr;
11(1):9046.
PMID: 33907233
Human Nbs1, a component of the MRN complex involved in DNA double strand break repair, contains a concatenated N-terminal FHA-BRCT1/2 sequence that supports interaction with multiple phosphopeptide binding partners. MDC1...
8.
London R
DNA Repair (Amst)
. 2020 Oct;
93:102917.
PMID: 33087283
X-ray cross complementing protein 1 (XRCC1) is a DNA repair scaffold that supports base excision repair and single strand break repair, and is also a participant in other repair pathways....
9.
Collins B, Kerns S, Aillon K, Mueller G, Rider C, DeRose E, et al.
Anal Bioanal Chem
. 2020 Sep;
412(25):6789-6809.
PMID: 32865633
Ginkgo biloba extract (GbE) is a dietary supplement derived from an ethanolic extract of Ginkgo biloba leaves. Unfinished bulk GbE is used to make finished products that are sold as...
10.
Duff Jr M, Gabel S, Pedersen L, DeRose E, Krahn J, Howell E, et al.
J Med Chem
. 2020 Jul;
63(15):8314-8324.
PMID: 32658475
Although nonsteroidal anti-inflammatory drugs (NSAIDs) target primarily cyclooxygenase enzymes, a subset of NSAIDs containing carboxylate groups also has been reported to competitively inhibit dihydrofolate reductase (DHFR). In this study, we...