Robert C Malenka
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Explore the profile of Robert C Malenka including associated specialties, affiliations and a list of published articles.
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177
Citations
26736
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Recent Articles
1.
Cardozo Pinto D, Pomrenze M, Guo M, Touponse G, Chen A, Bentzley B, et al.
Nature
. 2024 Nov;
639(8053):143-152.
PMID: 39586475
The neuromodulators dopamine (DA) and serotonin (5-hydroxytryptamine; 5HT) powerfully regulate associative learning. Similarities in the activity and connectivity of these neuromodulatory systems have inspired competing models of how DA and...
2.
St Laurent R, Kusche K, Rein B, Raymond K, Kreitzer A, Malenka R
Biol Psychiatry
. 2024 Nov;
97(7):707-720.
PMID: 39491639
Background: The avoidance of aversive stimuli through negative reinforcement learning, which demands dynamic responding to both positive and negative stimuli that often conflict with each other, is critical for survival...
3.
Pomrenze M, Vaillancourt S, Salgado J, Raymond K, Llorach P, Touponse G, et al.
bioRxiv
. 2024 Nov;
PMID: 39484424
MDMA is a promising adjunct to psychotherapy and has well-known abuse liability, although less than other amphetamine analogs. While the reinforcing dopamine (DA)-releasing properties of MDMA are on par with...
4.
Feng A, Barbosa D, Casey A, Rijsketic D, Salgado J, Huang H, et al.
bioRxiv
. 2024 Sep;
PMID: 39314466
Nucleus accumbens (NAc) deep brain stimulation (DBS) has been increasingly explored as a treatment modality for refractory neuropsychiatric disorders. Uncovering the accumbens network that is engaged by DBS is a...
5.
Yalcin B, Pomrenze M, Malacon K, Drexler R, Rogers A, Shamardani K, et al.
Nature
. 2024 Jun;
630(8017):677-685.
PMID: 38839962
All drugs of abuse induce long-lasting changes in synaptic transmission and neural circuit function that underlie substance-use disorders. Another recently appreciated mechanism of neural circuit plasticity is mediated through activity-regulated...
6.
Rein B, Raymond K, Boustani C, Tuy S, Zhang J, St Laurent R, et al.
Sci Adv
. 2024 Apr;
10(17):eadl6554.
PMID: 38657057
MDMA (3,4-methylenedioxymethamphetamine) is a psychoactive drug with powerful prosocial effects. While MDMA is sometimes termed an "empathogen," empirical studies have struggled to clearly demonstrate these effects or pinpoint underlying mechanisms....
7.
Pomrenze M, Vaillancourt S, Llorach P, Rijsketic D, Casey A, Gregory N, et al.
bioRxiv
. 2024 Mar;
PMID: 38496451
Ketamine has anesthetic, analgesic, and antidepressant properties which may involve multiple neuromodulatory systems. In humans, the opioid receptor (OR) antagonist naltrexone blocks the antidepressant effect of ketamine. It is unclear...
8.
Eshel N, Touponse G, Wang A, Osterman A, Shank A, Groome A, et al.
Neuron
. 2023 Nov;
112(3):500-514.e5.
PMID: 38016471
Striatal dopamine (DA) release has long been linked to reward processing, but it remains controversial whether DA release reflects costs or benefits and how these signals vary with motivation. Here,...
9.
Barbosa D, Gattas S, Salgado J, Kuijper F, Wang A, Huang Y, et al.
Nature
. 2023 Aug;
621(7978):381-388.
PMID: 37648849
Only recently have more specific circuit-probing techniques become available to inform previous reports implicating the rodent hippocampus in orexigenic appetitive processing. This function has been reported to be mediated at...
10.
Gore F, Hernandez M, Ramakrishnan C, Crow A, Malenka R, Deisseroth K
Nat Neurosci
. 2023 Aug;
26(9):1566-1574.
PMID: 37592039
Animals must continually evaluate stimuli in their environment to decide which opportunities to pursue, and in many cases these decisions can be understood in fundamentally economic terms. Although several brain...