Riya Shrestha
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Explore the profile of Riya Shrestha including associated specialties, affiliations and a list of published articles.
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16
Citations
65
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Recent Articles
1.
Quinlan J, Salamoun J, Garcia C, Hargett S, Beretta M, Shrestha R, et al.
Bioorg Med Chem
. 2024 Dec;
118():118045.
PMID: 39740573
Chemical mitochondrial uncouplers are protonophoric, lipophilic small molecules that transport protons from the mitochondrial intermembrane space into the matrix independent of ATP synthase, thus uncoupling nutrient oxidation from ATP production....
2.
Foutz M, Krinos E, Beretta M, Hargett S, Shrestha R, Murray J, et al.
J Med Chem
. 2024 Nov;
67(23):21486-21504.
PMID: 39614818
Mitochondrial uncouplers are small molecule protonophores that act to dissipate the proton motive force independent of adenosine triphosphate (ATP) synthase. Mitochondrial uncouplers such as BAM15 increase respiration and energy expenditure...
3.
Shrestha R, Vancuylenburg C, Beretta M, Zhou M, Shah D, Olzomer E, et al.
Cancer Metab
. 2024 Nov;
12(1):34.
PMID: 39538356
Background: The metabolic pathway of de novo lipogenesis (DNL) is upregulated in fatty liver disease and liver cancer. Inhibitors of DNL are in development for the treatment of these disorders;...
4.
Salamoun J, Krinos E, Foutz M, Hargett S, Beretta M, Shrestha R, et al.
Eur J Med Chem
. 2024 Oct;
280:116916.
PMID: 39406121
Small molecule mitochondrial uncouplers have gained traction for their potential therapeutic use against metabolic dysfunction-associated steatohepatitis (MASH). Herein, we report a novel imidazo[4,5-b]pyridine scaffold derived from iterative modifications of the...
5.
Hargett S, Lahiri S, Kowalski G, Corley S, Nelson M, Lackner C, et al.
Biochim Biophys Acta Mol Basis Dis
. 2024 Feb;
1870(3):167029.
PMID: 38325224
High fructose diets are associated with an increased risk of liver cancer. Previous studies in mice suggest increased lipogenesis is a key mechanism linking high fructose diets to liver tumour...
6.
Yadav V, Irfan R, Safdar S, Sunkara V, Ekhator C, Pendyala P, et al.
Cureus
. 2023 Aug;
15(8):e43973.
PMID: 37622052
Autoimmune hepatitis (AIH) is a chronic liver disease characterized by immune-mediated destruction of hepatocytes, leading to inflammation and fibrosis. In recent years, significant advances have been made in understanding the...
7.
Shrestha R, Karki S, Timilsina B, Sherpa T, Sapkota S, Dhakal B, et al.
Ann Med Surg (Lond)
. 2022 Oct;
82:104607.
PMID: 36268394
Introduction And Importance: Bud-Chiari syndrome is an uncommon disease due to obstruction of hepatic venous outflow. Clinical manifestations range from asymptomatic cases to those requiring liver transplants. The study highlights...
8.
Shrestha R, Johnson E, Byrne F
Mol Metab
. 2021 Mar;
51:101222.
PMID: 33781939
Background: Mitochondrial uncouplers are well-known for their ability to treat a myriad of metabolic diseases, including obesity and fatty liver diseases. However, for many years now, mitochondrial uncouplers have also...
9.
Kim Y, Jo J, Cho P, Shrestha R, Kim K, Ki S, et al.
Biopharm Drug Dispos
. 2020 Jun;
41(7):295-306.
PMID: 32557706
Ginseng (Panax ginseng Meyer) is a popular traditional herbal medicine used worldwide. Patients often take ginseng preparations with other medicines where the ginseng dose could exceed the recommended dose during...
10.
Paudel S, Shrestha A, Cho P, Shrestha R, Kim Y, Lee T, et al.
Pharmaceutics
. 2019 Sep;
11(9).
PMID: 31527544
Loxoprofen (LOX) is a non-selective cyclooxygenase inhibitor that is widely used for the treatment of pain and inflammation caused by chronic and transitory conditions. Its alcoholic metabolites are formed by...