Rimma Belotserkovskaya
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Explore the profile of Rimma Belotserkovskaya including associated specialties, affiliations and a list of published articles.
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18
Citations
2224
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Recent Articles
1.
Awwad S, Doyle C, Coulthard J, Bader A, Gueorguieva N, Lam S, et al.
Nat Commun
. 2025 Jan;
16(1):480.
PMID: 39779698
ATR plays key roles in cellular responses to DNA damage and replication stress, a pervasive feature of cancer cells. ATR inhibitors (ATRi) are in clinical development for treating various cancers,...
2.
Goh C, Bader A, Tran T, Belotserkovskaya R, DAlessandro G, Jackson S
Nucleic Acids Res
. 2024 Dec;
53(2.
PMID: 39660638
HAP1 is a near-haploid human cell line commonly used for mutagenesis and genome editing studies due to its hemizygous nature. We noticed an unusual hypersensitivity of HAP1 to camptothecin, an...
3.
DAlessandro G, Morales-Juarez D, Richards S, Nitiss K, Serrano-Benitez A, Wang J, et al.
Sci Adv
. 2023 Dec;
9(49):eadl2108.
PMID: 38055822
The catalytic cycle of topoisomerase 2 (TOP2) enzymes proceeds via a transient DNA double-strand break (DSB) intermediate termed the TOP2 cleavage complex (TOP2cc), in which the TOP2 protein is covalently...
4.
Belotserkovskaya R, Raga Gil E, Lawrence N, Butler R, Clifford G, Wilson M, et al.
Nat Commun
. 2020 Feb;
11(1):819.
PMID: 32041954
Loss of functional BRCA1 protein leads to defects in DNA double-strand break (DSB) repair by homologous recombination (HR) and renders cells hypersensitive to poly (ADP-ribose) polymerase (PARP) inhibitors used to...
5.
Salguero I, Belotserkovskaya R, Coates J, Sczaniecka-Clift M, Demir M, Jhujh S, et al.
Nat Commun
. 2019 Nov;
10(1):5191.
PMID: 31729360
Histone H2AX and MDC1 are key DNA repair and DNA-damage signalling proteins. When DNA double-strand breaks (DSBs) occur, H2AX is phosphorylated and then recruits MDC1, which in turn serves as...
6.
Cornwell M, Thomson G, Coates J, Belotserkovskaya R, Waddell I, Jackson S, et al.
ACS Chem Biol
. 2019 Sep;
14(10):2148-2154.
PMID: 31525021
The Fanconi anemia pathway orchestrates the repair of DNA interstrand cross-links and stalled replication forks. A key step in this pathway is UBE2T and FANCL-dependent monoubiquitylation of the FANCD2-FANCI complex....
7.
Dev H, Chiang T, Lescale C, de Krijger I, Martin A, Pilger D, et al.
Nat Cell Biol
. 2018 Jul;
20(8):954-965.
PMID: 30022119
BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. To understand the resistance mechanisms, we conducted whole-genome CRISPR-Cas9 synthetic-viability/resistance screens in...
8.
Davies O, Forment J, Sun M, Belotserkovskaya R, Coates J, Galanty Y, et al.
Nat Struct Mol Biol
. 2015 Jan;
22(2):150-157.
PMID: 25558984
Mammalian CtIP protein has major roles in DNA double-strand break (DSB) repair. Although it is well established that CtIP promotes DNA-end resection in preparation for homology-dependent DSB repair, the molecular...
9.
Belotserkovskaya R, Jackson S
Cell Res
. 2014 May;
24(7):781-2.
PMID: 24810302
A recent study published in Science reveals the mechanism and biological importance of DNA damage response abrogation in mitotic cells.
10.
Knobel P, Belotserkovskaya R, Galanty Y, Schmidt C, Jackson S, Stracker T
Mol Cell Biol
. 2014 Apr;
34(11):2062-74.
PMID: 24687851
The DNA damage response (DDR) is critical for genome stability and the suppression of a wide variety of human malignancies, including neurodevelopmental disorders, immunodeficiency, and cancer. In addition, the efficacy...