Giuseppina DAlessandro
Overview
Explore the profile of Giuseppina DAlessandro including associated specialties, affiliations and a list of published articles.
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44
Citations
1082
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Recent Articles
1.
Rosito M, Maqbool J, Reccagni A, Mangano M, DAndrea T, Rinaldi A, et al.
Cell Mol Life Sci
. 2025 Feb;
82(1):73.
PMID: 39921723
The use of a ketogenic diet (KD) in glioma is currently tested as an adjuvant treatment in standard chemotherapy regimens. The metabolic shift induced by the KD leads to the...
2.
Muffels I, Waterham H, DAlessandro G, Zagnoli-Vieira G, Sacher M, Lefeber D, et al.
Genome Med
. 2025 Feb;
17(1):12.
PMID: 39920830
Background: Deciphering variants of uncertain significance (VUS) represents a major diagnostic challenge, partially due to the lack of easy-to-use and versatile cellular readouts that aid the interpretation of pathogenicity and...
3.
Goh C, Bader A, Tran T, Belotserkovskaya R, DAlessandro G, Jackson S
Nucleic Acids Res
. 2024 Dec;
53(2.
PMID: 39660638
HAP1 is a near-haploid human cell line commonly used for mutagenesis and genome editing studies due to its hemizygous nature. We noticed an unusual hypersensitivity of HAP1 to camptothecin, an...
4.
Kochenova O, DAlessandro G, Pilger D, Schmid E, Richards S, Garcia M, et al.
bioRxiv
. 2024 Sep;
PMID: 39282314
The E3 ubiquitin ligase TRAIP associates with the replisome and helps this molecular machine deal with replication stress. Thus, TRAIP promotes DNA inter-strand crosslink repair by triggering the disassembly of...
5.
Garofalo S, DAlessandro G, Limatola C
Adv Neurobiol
. 2024 Aug;
37:513-527.
PMID: 39207710
Myeloid cells are fundamental constituents of the brain tumor microenvironment. In this chapter, we describe the state-of-the-art knowledge on the role of microglial cells in the cross-talk with the most...
6.
Rinaldi A, Balietti M, Principi E, De Luca M, De Felice E, Narcisi F, et al.
Brain Behav Immun
. 2024 Aug;
122:58-74.
PMID: 39128568
Background: During aging, both the brain and the immune system undergo a progressive impairment of physiological functions. Microglia, the immunocompetent cells of the central nervous system, shift towards a chronic...
7.
Carnie C, Gotz M, Palma-Chaundler C, Weickert P, Wanders A, Serrano-Benitez A, et al.
EMBO J
. 2024 May;
43(12):2397-2423.
PMID: 38760575
The nucleoside analogue decitabine (or 5-aza-dC) is used to treat several haematological cancers. Upon its triphosphorylation and incorporation into DNA, 5-aza-dC induces covalent DNA methyltransferase 1 DNA-protein crosslinks (DNMT1-DPCs), leading...
8.
Marrocco F, Falvo E, Mosca L, Tisci G, Arcovito A, Reccagni A, et al.
Cell Death Dis
. 2024 Apr;
15(4):262.
PMID: 38615026
Gliomas are among the most fatal tumors, and the available therapeutic options are very limited. Additionally, the blood-brain barrier (BBB) prevents most drugs from entering the brain. We designed and...
9.
Carnie C, Acampora A, Bader A, Erdenebat C, Zhao S, Bitensky E, et al.
Nat Cell Biol
. 2024 Apr;
26(5):797-810.
PMID: 38600235
Covalent DNA-protein cross-links (DPCs) are toxic DNA lesions that block replication and require repair by multiple pathways. Whether transcription blockage contributes to the toxicity of DPCs and how cells respond...
10.
Rosito M, Maqbool J, Reccagni A, Giampaoli O, Sciubba F, Antonangeli F, et al.
Cell Death Dis
. 2024 Mar;
15(3):210.
PMID: 38480690
In recent years, several studies described the close relationship between the composition of gut microbiota and brain functions, highlighting the importance of gut-derived metabolites in mediating neuronal and glial cells...