Richard W Gross
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Explore the profile of Richard W Gross including associated specialties, affiliations and a list of published articles.
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117
Citations
7492
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Recent Articles
1.
Moon S, Liu X, Jenkins C, Dilthey B, Patti G, Gross R
J Lipid Res
. 2024 Aug;
65(9):100611.
PMID: 39094773
Mitochondrial fatty acid oxidation serves as an essential process for cellular survival, differentiation, proliferation, and energy metabolism. Numerous studies have utilized etomoxir (ETO) for the irreversible inhibition of carnitine palmitoylcarnitine...
2.
Moon S, Dilthey B, Guan S, Sims H, Pittman S, Keith A, et al.
iScience
. 2023 Jun;
26(6):106895.
PMID: 37275531
Skeletal muscle is the major site of glucose utilization in mammals integrating serum glucose clearance with mitochondrial respiration. To mechanistically elucidate the roles of iPLAγ in skeletal muscle mitochondria, we...
3.
Cifarelli V, Kuda O, Yang K, Liu X, Gross R, Pietka T, et al.
Front Cardiovasc Med
. 2022 Sep;
9:948332.
PMID: 36061565
CD36 mediates the uptake of long-chain fatty acids (FAs), a major energy substrate for the myocardium. Under excessive FA supply, CD36 can cause cardiac lipid accumulation and inflammation while its...
4.
Han X, Gross R
J Lipid Res
. 2021 Dec;
63(2):100164.
PMID: 34953866
For over a century, the importance of lipid metabolism in biology was recognized but difficult to mechanistically understand due to the lack of sensitive and robust technologies for identification and...
5.
Moon S, Dilthey B, Liu X, Guan S, Sims H, Gross R
J Lipid Res
. 2021 Feb;
62:100052.
PMID: 33636162
High-fat (HF) diet-induced obesity precipitates multiple metabolic disorders including insulin resistance, glucose intolerance, oxidative stress, and inflammation, resulting in the initiation of cell death programs. Previously, we demonstrated murine germline...
6.
McCommis K, Kovacs A, Weinheimer C, Shew T, Koves T, Ilkayeva O, et al.
Nat Metab
. 2020 Oct;
2(11):1232-1247.
PMID: 33106690
The myocardium is metabolically flexible; however, impaired flexibility is associated with cardiac dysfunction in conditions including diabetes and heart failure. The mitochondrial pyruvate carrier (MPC) complex, composed of MPC1 and...
7.
Liu G, Moon S, Jenkins C, Sims H, Guan S, Gross R
J Biol Chem
. 2020 Jul;
295(34):12167-12180.
PMID: 32641497
Recently, eicosanoid-lysophospholipids were identified as novel metabolites generated from the direct cyclooxygenase- or lipoxygenase-catalyzed oxidation of 2-arachidonoyl-lysophospholipids produced from either phospholipase A-mediated hydrolysis of diacyl arachidonoyl-phospholipids or through the cytochrome...
8.
Liu X, Sims H, Jenkins C, Guan S, Dilthey B, Gross R
J Biol Chem
. 2020 Mar;
295(16):5307-5320.
PMID: 32161117
The canonical pathway of eicosanoid production in most mammalian cells is initiated by phospholipase A-mediated release of arachidonic acid, followed by its enzymatic oxidation resulting in a vast array of...
9.
Liu G, Moon S, Jenkins C, Sims H, Guan S, Gross R
J Biol Chem
. 2019 May;
294(26):10146-10159.
PMID: 31080170
Recently, oxidized phospholipid species have emerged as important signaling lipids in activated immune cells and platelets. The canonical pathway for the synthesis of oxidized phospholipids is through the release of...
10.
Li W, Feng G, Gauthier J, Lokshina I, Higashikubo R, Evans S, et al.
J Clin Invest
. 2019 Mar;
129(6):2293-2304.
PMID: 30830879
Non-apoptotic forms of cell death can trigger sterile inflammation through the release of danger-associated molecular patterns, which are recognized by innate immune receptors. However, despite years of investigation the mechanisms...