Richard T Premont
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Explore the profile of Richard T Premont including associated specialties, affiliations and a list of published articles.
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109
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5201
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Recent Articles
1.
Sun Q, Grimmett Z, Hess D, Perez L, Qian Z, Chaube R, et al.
Biochem Biophys Res Commun
. 2024 May;
723:150163.
PMID: 38820626
Excitation-contraction coupling in skeletal muscle myofibers depends upon Ca release from the sarcoplasmic reticulum through the ryanodine receptor/Ca-release channel RyR1. The RyR1 contains ∼100 Cys thiols of which ∼30 comprise...
2.
Moyal A, Nazemian R, Colon E, Zhu L, Benzar R, Palmer N, et al.
Ann Med Surg (Lond)
. 2024 May;
86(5):2425-2431.
PMID: 38694342
Background: Impaired kidney function is frequently observed in patients following cardiopulmonary bypass (CPB). Our group has previously linked blood transfusion to acute declines in S-nitroso haemoglobin (SNO-Hb; the main regulator...
3.
Venetos N, Stomberski C, Qian Z, Premont R, Stamler J
J Lipid Res
. 2024 Apr;
65(5):100542.
PMID: 38641009
Nitric oxide (NO), produced primarily by nitric oxide synthase enzymes, is known to influence energy metabolism by stimulating fat uptake and oxidation. The effects of NO on de novo lipogenesis...
4.
Zhou H, Grimmett Z, Venetos N, Stomberski C, Qian Z, McLaughlin P, et al.
Cell
. 2023 Dec;
186(26):5812-5825.e21.
PMID: 38056462
Acyl-coenzyme A (acyl-CoA) species are cofactors for numerous enzymes that acylate thousands of proteins. Here, we describe an enzyme that uses S-nitroso-CoA (SNO-CoA) as its cofactor to S-nitrosylate multiple proteins...
5.
Seth P, Hausladen A, Premont R, Stamler J
STAR Protoc
. 2023 Nov;
4(4):102430.
PMID: 37925633
S-nitrosothiol (SNO)-Resin Assisted Capture (SNO-RAC) relies on a Thiopropyl Sepharose resin to identify S-nitrosylated proteins (SNO-proteins) and sites of S-nitrosylation. Here, we present a protocol for preparing Thiopropyl Sepharose resin...
6.
Seth D, Stomberski C, McLaughlin P, Premont R, Lundberg K, Stamler J
Antioxid Redox Signal
. 2023 Apr;
39(10-12):621-634.
PMID: 37053107
S-nitrosylation of proteins is the main mechanism through which nitric oxide (NO) regulates cellular function and likely represents the archetype redox-based signaling system across aerobic and anaerobic organisms. How NO...
7.
Zhou H, Hausladen A, Anand P, Rajavel M, Stomberski C, Zhang R, et al.
J Med Chem
. 2023 Apr;
66(8):5657-5668.
PMID: 37027003
Acute kidney injury (AKI) is associated with high morbidity and mortality, and no drugs are available clinically. Metabolic reprogramming resulting from the deletion of S-nitroso-coenzyme A reductase 2 (SCoR2; AKR1A1)...
8.
Reynolds J, Posina K, Zhu L, Jenkins T, Matto F, Hausladen A, et al.
Proc Natl Acad Sci U S A
. 2023 Feb;
120(9):e2220769120.
PMID: 36812211
S-Nitrosohemoglobin (SNO-Hb) is unique among vasodilators in coupling blood flow to tissue oxygen requirements, thus fulfilling an essential function of the microcirculation. However, this essential physiology has not been tested...
9.
Gerhards J, Maerz L, Matthees E, Donow C, Moepps B, Premont R, et al.
J Am Soc Nephrol
. 2023 Feb;
34(4):590-606.
PMID: 36810260
Significance Statement: G protein-coupled receptor kinase 4 (GRK4) regulates renal sodium and water reabsorption. Although GRK4 variants with elevated kinase activity have been associated with salt-sensitive or essential hypertension, this...
10.
Stomberski C, Venetos N, Zhou H, Qian Z, Collison B, Field S, et al.
Cell Rep
. 2022 Oct;
41(4):111538.
PMID: 36288700
Accumulating evidence suggests that protein S-nitrosylation is enzymatically regulated and that specificity in S-nitrosylation derives from dedicated S-nitrosylases and denitrosylases that conjugate and remove S-nitrosothiols, respectively. Here, we report that...