Robert J Lefkowitz
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Explore the profile of Robert J Lefkowitz including associated specialties, affiliations and a list of published articles.
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203
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21500
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Recent Articles
1.
Kahsai A, Pakharukova N, Kwon H, Shah K, Liang-Lin J, Del Real C, et al.
bioRxiv
. 2025 Jan;
PMID: 39763753
Highlights: Small molecule strategies for modulating βarr functions in both GPCR-dependent and independent contexts.Modulators disrupt βarr interaction with GPCRs, impairing their critical functions.Cryo-EM structures reveal the allosteric inhibitor Cmpd-5 binding...
2.
Cech T, Charpentier E, Ciechanover A, Lefkowitz R, Wuthrich K
Cell Chem Biol
. 2024 Aug;
31(8):1388-1390.
PMID: 39151404
Since the first award in 1901, the Nobel Prize has come to signify the pinnacle of scientific achievement. In this Voices piece in the August special issue of Cell Chemical...
3.
Pakharukova N, Thomas B, Bansia H, Li L, Abzalimov R, Kim J, et al.
bioRxiv
. 2024 Aug;
PMID: 39131402
Beta-arrestins (βarrs) are key regulators and transducers of G-protein coupled receptor signaling; however, little is known of how βarrs communicate with their downstream effectors. Here, we use cryo-electron microscopy to...
4.
Liu S, Anderson P, Rajagopal S, Lefkowitz R, Rockman H
Circ Res
. 2024 Jun;
135(1):174-197.
PMID: 38900852
GPCRs (G protein-coupled receptors), also known as 7 transmembrane domain receptors, are the largest receptor family in the human genome, with ≈800 members. GPCRs regulate nearly every aspect of human...
5.
Casiraghi M, Wang H, Brennan P, Habrian C, Hubner H, Schmidt M, et al.
bioRxiv
. 2024 Apr;
PMID: 38586060
G protein coupled receptors (GPCRs) exhibit varying degrees of selectivity for different G protein isoforms. Despite the abundant structures of GPCR-G protein complexes, little is known about the mechanism of...
6.
Rockman H, Lefkowitz R
J Clin Invest
. 2024 Mar;
134(5).
PMID: 38426490
Radioligand binding techniques facilitated the identification and study of G-protein coupled receptors that now represent the largest class of targets for therapeutic drugs.
7.
Lefkowitz R, Rockman H, Shim P, Liu S, Ahn S, Pani B, et al.
Nat Commun
. 2023 Nov;
14(1):7866.
PMID: 38036531
No abstract available.
8.
Kahsai A, Shah K, Shim P, Lee M, Shreiber B, Schwalb A, et al.
Proc Natl Acad Sci U S A
. 2023 Oct;
120(43):e2303794120.
PMID: 37844230
β-arrestins are multivalent adaptor proteins that bind active phosphorylated G protein-coupled receptors (GPCRs) to inhibit G protein signaling, mediate receptor internalization, and initiate alternative signaling events. β-arrestins link agonist-stimulated GPCRs...
9.
Ahn S, Maarsingh H, Walker J, Liu S, Hegde A, Sumajit H, et al.
J Clin Invest
. 2023 Jul;
133(18).
PMID: 37432742
Asthma is a chronic inflammatory disease associated with episodic airway narrowing. Inhaled β2-adrenergic receptor (β2AR) agonists (β2-agonists) promote - with limited efficacy - bronchodilation in asthma. All β2-agonists are canonical...
10.
Li A, Liu S, Huang R, Ahn S, Lefkowitz R
PLoS One
. 2023 Mar;
18(3):e0283477.
PMID: 36961836
G protein-coupled receptors (GPCRs) regulate cellular signaling pathways by coupling to two classes of transducers: heterotrimeric G proteins and β-arrestins. [Sarcosine1Ile4Ile8]-angiotensin II (SII), an analog of the endogenous ligand angiotensin...