Richard S Eisenstein
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Explore the profile of Richard S Eisenstein including associated specialties, affiliations and a list of published articles.
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31
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1462
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Recent Articles
11.
Chung J, Anderson S, Gwynn B, Deck K, Chen M, Langer N, et al.
J Biol Chem
. 2014 Feb;
289(11):7835-43.
PMID: 24509859
Mitochondrial iron is essential for the biosynthesis of heme and iron-sulfur ([Fe-S]) clusters in mammalian cells. In developing erythrocytes, iron is imported into the mitochondria by MFRN1 (mitoferrin-1, SLC25A37). Although...
12.
Anderson S, Nizzi C, Chang Y, Deck K, Schmidt P, Galy B, et al.
Cell Metab
. 2013 Feb;
17(2):282-90.
PMID: 23395174
Red blood cell production is a finely tuned process that requires coordinated oxygen- and iron-dependent regulation of cell differentiation and iron metabolism. Here, we show that translational regulation of hypoxia-inducible...
13.
Ruiz J, Walker S, Anderson S, Eisenstein R, Bruick R
J Biol Chem
. 2012 Nov;
288(1):552-60.
PMID: 23135277
Maintenance of cellular iron homeostasis requires post-transcriptional regulation of iron metabolism genes by iron regulatory protein 2 (IRP2). The hemerythrin-like domain of F-box and leucine-rich repeat protein 5 (FBXL5), an...
14.
Anderson C, Shen M, Eisenstein R, Leibold E
Biochim Biophys Acta
. 2012 May;
1823(9):1468-83.
PMID: 22610083
Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2). IRPs bind to iron-responsive elements (IREs) located in the untranslated regions of mRNAs encoding protein...
15.
Zhang A, Anderson S, Wang J, Yang F, DeMaster K, Ahmed R, et al.
Blood
. 2010 Dec;
117(5):1687-99.
PMID: 21115976
Recent studies demonstrate a pivotal role for bone morphogenic protein-6 (BMP6) and matriptase-2, a protein encoded by the TMPRSS6 gene, in the induction and suppression of hepatic hepcidin expression, respectively....
16.
Goforth J, Anderson S, Nizzi C, Eisenstein R
RNA
. 2009 Nov;
16(1):154-69.
PMID: 19939970
Iron regulatory proteins (IRPs) are iron-regulated RNA binding proteins that, along with iron-responsive elements (IREs), control the translation of a diverse set of mRNA with 5' IRE. Dysregulation of IRP...
17.
Deck K, Vasanthakumar A, Anderson S, Goforth J, Kennedy M, Antholine W, et al.
J Biol Chem
. 2009 Mar;
284(19):12701-9.
PMID: 19269970
Iron-sulfur cluster-dependent interconversion of iron regulatory protein 1 (IRP1) between its RNA binding and cytosolic aconitase (c-acon) forms controls vertebrate iron homeostasis. Cluster removal from c-acon is thought to include...
18.
Dos Santos C, Dore L, Valentine E, Shelat S, Hardison R, Ghosh M, et al.
J Biol Chem
. 2008 Aug;
283(40):26956-64.
PMID: 18676996
Hemoglobin production during erythropoiesis is mechanistically coupled to the acquisition and metabolism of iron. We discovered that iron regulates the expression of alpha-hemoglobin-stabilizing protein (AHSP), a molecular chaperone that binds...
19.
Stehling O, Netz D, Niggemeyer B, Rosser R, Eisenstein R, Puccio H, et al.
Mol Cell Biol
. 2008 Jun;
28(17):5517-28.
PMID: 18573874
The maturation of cytosolic iron-sulfur (Fe/S) proteins in mammalian cells requires components of the mitochondrial iron-sulfur cluster assembly and export machineries. Little is known about the cytosolic components that may...
20.
Zhang A, Anderson S, Meyers K, Hernandez C, Eisenstein R, Enns C
J Biol Chem
. 2007 Mar;
282(17):12547-56.
PMID: 17331953
Hemojuvelin (HJV), encoded by the gene HFE2, is a critical upstream regulator of hepcidin expression. Hepcidin, the central iron regulatory hormone, is secreted from hepatocytes, whereas HFE2 is highly expressed...