Richard N Sifers
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Explore the profile of Richard N Sifers including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
695
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Recent Articles
21.
Wu Y, Termine D, Swulius M, Moremen K, Sifers R
J Biol Chem
. 2006 Dec;
282(7):4841-4849.
PMID: 17166854
In the early secretory pathway, opportunistic cleavage of asparagine-linked oligosaccharides by endoplasmic reticulum (ER) mannosidase I targets misfolded glycoproteins for dislocation into the cytosol and destruction by 26 S proteasomes....
22.
Termine D, Wu Y, Liu Y, Sifers R
Methods
. 2005 Apr;
35(4):348-53.
PMID: 15804606
It is now understood that a cohesive series of quality control checkpoints ensures the accuracy of gene expression in eukaryotic cells. Although initiated in the nucleus to monitor the integrity...
23.
Mast S, Diekman K, Karaveg K, Davis A, Sifers R, Moremen K
Glycobiology
. 2004 Nov;
15(4):421-36.
PMID: 15537790
In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). Early in this pathway, a...
24.
25.
Wu Y, Swulius M, Moremen K, Sifers R
Proc Natl Acad Sci U S A
. 2003 Jun;
100(14):8229-34.
PMID: 12815101
The exocytic pathway provides a physical route through which newly synthesized secretory and membrane proteins are deployed to the eukaryote cell surface. For newly synthesized alpha1-antitrypsin (AAT), the modification of...
26.
27.
Cabral C, Liu Y, Moremen K, Sifers R
Mol Biol Cell
. 2002 Aug;
13(8):2639-50.
PMID: 12181335
Protein folding and quality control in the early secretory pathway function as posttranslational checkpoints in eukaryote gene expression. Herein, an aberrant form of the hepatic secretory protein alpha1-antitrypsin was stably...
28.
Han B, Luo G, Shi Z, Barrios R, Atwood D, Liu W, et al.
Am J Pathol
. 2002 Aug;
161(2):481-90.
PMID: 12163373
The metabolism of cysteinyl leukotrienes in vivo and the pathophysiological effects of individual cysteinyl leukotrienes are primarily unknown. Recently we identified an additional member of the gamma-glutamyl transpeptidase (GGT) family,...
29.
Davis R, Shrimpton A, Carrell R, Lomas D, Gerhard L, Baumann B, et al.
Lancet
. 2002 Jul;
359(9325):2242-7.
PMID: 12103288
Background: The aggregation of specific proteins is a common feature of the familial dementias, but whether the formation of neuronal inclusion bodies is a causative or incidental factor in the...