Richard N Sifers
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Explore the profile of Richard N Sifers including associated specialties, affiliations and a list of published articles.
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29
Citations
695
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Recent Articles
11.
Fong J, Nguyen B, Bridger R, Medrano E, Wells L, Pan S, et al.
J Biol Chem
. 2012 Feb;
287(15):12195-203.
PMID: 22371497
O-Linked β-N-acetylglucosamine, or O-GlcNAc, is a dynamic post-translational modification that cycles on and off serine and threonine residues of nucleocytoplasmic proteins. The O-GlcNAc modification shares a complex relationship with phosphorylation,...
12.
Pan S, Wang S, Utama B, Huang L, Blok N, Estes M, et al.
Mol Biol Cell
. 2011 Jun;
22(16):2810-22.
PMID: 21697506
The Golgi complex has been implicated as a possible component of endoplasmic reticulum (ER) glycoprotein quality control, although the elucidation of its exact role is lacking. ERManI, a putative ER...
13.
Pan S, Iannotti M, Sifers R
Methods Enzymol
. 2011 Jun;
499:1-16.
PMID: 21683246
Biological checkpoints are known to function in the cellular nucleus to monitor the integrity of inherited genetic information. It is now understood that posttranslational checkpoint systems operate in numerous biosynthetic...
14.
Sifers R
Proc Am Thorac Soc
. 2010 Oct;
7(6):376-80.
PMID: 21030516
α(1)-Antitrypsin (AAT) secreted from hepatocytes is an inhibitor of neutrophil elastase. Its normal circulating concentration functions to maintain the elasticity of the lung by preventing the hydrolytic destruction of elastin...
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Pan S, Huang L, McPherson J, Muzny D, Rouhani F, Brantly M, et al.
Hepatology
. 2009 May;
50(1):275-81.
PMID: 19444872
Unlabelled: Inappropriate accumulation of the misfolded Z variant of alpha1-antitrypsin in the hepatocyte endoplasmic reticulum (ER) is a risk factor for the development of end-stage liver disease. However, the genetic...
19.
Termine D, Moremen K, Sifers R
J Cell Sci
. 2009 Mar;
122(Pt 7):976-84.
PMID: 19258393
The secretory pathway provides a physical route through which only correctly folded gene products are delivered to the eukaryotic cell surface. The efficiency of endoplasmic reticulum (ER)-associated degradation (ERAD), which...
20.
Mallya M, Phillips R, Saldanha S, Gooptu B, Brown S, Termine D, et al.
J Med Chem
. 2007 Oct;
50(22):5357-63.
PMID: 17918823
The Z mutant of alpha1-antitrypsin (Glu342Lys) causes a domain swap and the formation of intrahepatic polymers that aggregate as inclusions and predispose the homozygote to cirrhosis. We have identified an...