Richard Mulligan
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Explore the profile of Richard Mulligan including associated specialties, affiliations and a list of published articles.
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14
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1928
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Recent Articles
1.
Sahin E, Colla S, Liesa M, Moslehi J, Muller F, Guo M, et al.
Nature
. 2011 Feb;
470(7334):359-65.
PMID: 21307849
Telomere dysfunction activates p53-mediated cellular growth arrest, senescence and apoptosis to drive progressive atrophy and functional decline in high-turnover tissues. The broader adverse impact of telomere dysfunction across many tissues...
2.
Danos O, Davies K, Lehn P, Mulligan R
J Gene Med
. 2010 Jul;
12(7):559-60.
PMID: 20603891
Here we introduce the ARRIVE (Animal Research: Reporting In Vivo Experiments) guidelines, produced by the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), which are...
3.
Paul R, Grieve S, Chaudary B, Gordon N, Lawrence J, Cooper N, et al.
Neurobiol Aging
. 2007 Sep;
30(3):457-65.
PMID: 17869383
Recent research has revealed significant relationships between the vermian regions of the cerebellum and cognitive functions typically associated with prefrontal lobe function. These relationships are believed to be supported by...
4.
Chan R, Garfein E, Gigante P, Liu P, Agha R, Mulligan R, et al.
Plast Reconstr Surg
. 2007 Jul;
120(2):407-411.
PMID: 17632341
Background: Early evidence suggests that stem cells play a role in normal wound healing. Various impaired wound-healing states might be due to a deficiency in the stem cell repertoire. The...
5.
Kaipainen A, Kieran M, Huang S, Butterfield C, Bielenberg D, Mostoslavsky G, et al.
PLoS One
. 2007 Mar;
2(2):e260.
PMID: 17327920
Inflammation in the tumor bed can either promote or inhibit tumor growth. Peroxisome proliferator-activated receptor (PPAR)alpha is a central transcriptional suppressor of inflammation, and may therefore modulate tumor growth. Here...
6.
Simons J, Carducci M, Mikhak B, Lim M, Biedrzycki B, Borellini F, et al.
Clin Cancer Res
. 2006 Jun;
12(11 Pt 1):3394-401.
PMID: 16740763
Purpose: To determine the toxicity, immunologic, and clinical activity of immunotherapy with irradiated, allogeneic, prostate cancer cells expressing granulocyte macrophage colony-stimulating factor (GM-CSF) in patients with recurrent prostate cancer. Patients...
7.
Yan C, Kaushal D, Murphy M, Zhang Y, Datta A, Chen C, et al.
Proc Natl Acad Sci U S A
. 2006 May;
103(19):7378-83.
PMID: 16670198
Inactivation of the XRCC4 nonhomologous end-joining factor in the mouse germ line leads to embryonic lethality, in association with apoptosis of newly generated, postmitotic neurons. We now show that conditional...
8.
Mostoslavsky R, Chua K, Lombard D, Pang W, Fischer M, Gellon L, et al.
Cell
. 2006 Jan;
124(2):315-29.
PMID: 16439206
The Sir2 histone deacetylase functions as a chromatin silencer to regulate recombination, genomic stability, and aging in budding yeast. Seven mammalian Sir2 homologs have been identified (SIRT1-SIRT7), and it has...
9.
Tani K, Azuma M, Nakazaki Y, Oyaizu N, Hase H, Ohata J, et al.
Mol Ther
. 2004 Sep;
10(4):799-816.
PMID: 15451464
We produced lethally irradiated retrovirally GM-CSF-transduced autologous renal tumor cell vaccines (GVAX) from six Japanese patients with stage IV renal cell cancer (RCC). Four patients received GVAX ranging from 1.4...
10.
Soiffer R, Hodi F, Haluska F, Jung K, Gillessen S, Singer S, et al.
J Clin Oncol
. 2003 Aug;
21(17):3343-50.
PMID: 12947071
Purpose: Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor (GM-CSF) by retroviral-mediated gene transfer generates potent antitumor immunity in patients with metastatic melanoma. Further clinical development...