Richard Marcotte
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Explore the profile of Richard Marcotte including associated specialties, affiliations and a list of published articles.
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21
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1269
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Recent Articles
1.
Milanese J, Marcotte R, Costain W, Kablar B, Drouin S
Adv Anat Embryol Cell Biol
. 2023 Nov;
236:21-55.
PMID: 37955770
The ability to assess various cellular events consequent to perturbations, such as genetic mutations, disease states and therapies, has been recently revolutionized by technological advances in multiple "omics" fields. The...
2.
Lalonde M, Sasseville M, Gelinas A, Milanese J, Beland K, Drouin S, et al.
Haematologica
. 2022 Sep;
108(2):382-393.
PMID: 36134452
Acute lymphoblastic leukemia (ALL) is the most frequent cancer diagnosed in children. Despite the great progress achieved over the last 40 years, with cure rates now exceeding 85%, refractory or...
3.
Germline variants associated with leukocyte genes predict tumor recurrence in breast cancer patients
Milanese J, Tibiche C, Zou J, Meng Z, Nantel A, Drouin S, et al.
NPJ Precis Oncol
. 2019 Nov;
3:28.
PMID: 31701019
Germline variants such as BRCA1/2 play an important role in tumorigenesis and clinical outcomes of cancer patients. However, only a small fraction (i.e., 5-10%) of inherited variants has been associated...
4.
Nair N, Das A, Rogkoti V, Fokkelman M, Marcotte R, de Jong C, et al.
Sci Rep
. 2019 Jul;
9(1):10989.
PMID: 31358840
The efficacy of prospective cancer treatments is routinely estimated by in vitro cell-line proliferation screens. However, it is unclear whether tumor aggressiveness and patient survival are influenced more by the...
5.
Banh R, Iorio C, Marcotte R, Xu Y, Cojocari D, Abdel Rahman A, et al.
Nat Cell Biol
. 2016 Jun;
18(7):803-813.
PMID: 27323329
Tumours exist in a hypoxic microenvironment and must limit excessive oxygen consumption. Hypoxia-inducible factor (HIF) controls mitochondrial oxygen consumption, but how/if tumours regulate non-mitochondrial oxygen consumption (NMOC) is unknown. Protein-tyrosine...
6.
Marcotte R, Sayad A, Brown K, Sanchez-Garcia F, Reimand J, Haider M, et al.
Cell
. 2016 Jan;
164(1-2):293-309.
PMID: 26771497
Large-scale genomic studies have identified multiple somatic aberrations in breast cancer, including copy number alterations and point mutations. Still, identifying causal variants and emergent vulnerabilities that arise as a consequence...
7.
Hsu T, Simon L, Neill N, Marcotte R, Sayad A, Bland C, et al.
Nature
. 2015 Sep;
525(7569):384-8.
PMID: 26331541
MYC (also known as c-MYC) overexpression or hyperactivation is one of the most common drivers of human cancer. Despite intensive study, the MYC oncogene remains recalcitrant to therapeutic inhibition. MYC...
8.
Pal R, Ramdzan Z, Kaur S, Duquette P, Marcotte R, Leduy L, et al.
J Biol Chem
. 2015 Jul;
290(37):22520-31.
PMID: 26221032
CUX1 and CUX2 proteins are characterized by the presence of three highly similar regions called Cut repeats 1, 2, and 3. Although CUX1 is ubiquitously expressed, CUX2 plays an important...
9.
Cullis J, Meiri D, Jose Sandi M, Radulovich N, Kent O, Medrano M, et al.
Cancer Cell
. 2014 Feb;
25(2):181-95.
PMID: 24525234
Cellular transformation by oncogenic RAS engages the MAPK pathway under strict regulation by the scaffold protein KSR-1. Here, we report that the guanine nucleotide exchange factor GEF-H1 plays a critical...
10.
Marcotte R, Brown K, Suarez F, Sayad A, Karamboulas K, Krzyzanowski P, et al.
Cancer Discov
. 2012 May;
2(2):172-189.
PMID: 22585861
Unlabelled: Genomic analyses are yielding a host of new information on the multiple genetic abnormalities associated with specific types of cancer. A comprehensive description of cancer-associated genetic abnormalities can improve...