Richard Marcotte
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Explore the profile of Richard Marcotte including associated specialties, affiliations and a list of published articles.
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21
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1269
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Recent Articles
11.
Marcotte R, Smith H, Sanguin-Gendreau V, McDonough R, Muller W
Proc Natl Acad Sci U S A
. 2011 Jun;
109(8):2808-13.
PMID: 21628573
The tyrosine kinase c-Src is activated in a large proportion of breast cancers, in which it is thought to play a key role in promoting the malignant phenotype. c-Src activity...
12.
Marcotte R, Zhou L, Kim H, Roskelly C, Muller W
Mol Cell Biol
. 2009 Aug;
29(21):5858-71.
PMID: 19704002
Previous studies have demonstrated that c-Src tyrosine kinase interacts specifically with ErbB2, but not with other members of the epidermal growth factor receptor (EGFR) family. To identify the site of...
13.
Dillon R, Marcotte R, Hennessy B, Woodgett J, Mills G, Muller W
Cancer Res
. 2009 Jun;
69(12):5057-64.
PMID: 19491266
The phosphatidylinositol 3-kinase (PI3K)/Akt survival pathway is often dysregulated in cancer. Our previous studies have shown that coexpression of activated Akt1 with activated ErbB2 or polyoma virus middle T antigen...
14.
Marcotte R, Muller W
J Mammary Gland Biol Neoplasia
. 2008 Jul;
13(3):323-35.
PMID: 18651209
The advent of genetically engineered mouse models (GEMs) of human breast cancer, have provided important insight into molecular basis or human breast cancer. This review will focus on two of...
15.
Marcotte R, Chen J, Huard S, Wang E
J Cell Biochem
. 2005 Sep;
96(5):1071-85.
PMID: 16167342
c-Myc transcriptional activity in cells is dampened by the Mad family of transcriptional repressors. The expression of one member, hMad4, is increased in growth-arrested states such as quiescence or replicative...
16.
Marcotte R, Lacelle C, Wang E
Mech Ageing Dev
. 2004 Nov;
125(10-11):777-83.
PMID: 15541772
In replicative senescence, cells undergo permanent exit from cell cycle traverse; this is traditionally thought to occur at the end of a culture's in vitro life span, after serial passaging....
17.
Marcotte R, Qian J, Chen J, Wang E
J Cell Biochem
. 2003 May;
89(3):576-88.
PMID: 12761891
Mad family proteins have an antagonistic action on Myc-dependent cell proliferation and transformation. We isolated a human cDNA clone, human Mad4 (hMad4), encoding a polypeptide of 209 amino acid residues,...
18.
Marcotte R, Wang E
J Gerontol A Biol Sci Med Sci
. 2002 Jun;
57(7):B257-69.
PMID: 12084796
Forty years after its discovery, replicative senescence remains a rich source of information about cell-cycle regulation and the progression from a normal to a transformed phenotype. Effectors of this growth-arrested...
19.
Semov A, Semova N, Lacelle C, Marcotte R, Petroulakis E, Proestou G, et al.
FASEB J
. 2002 Jun;
16(8):899-901.
PMID: 12039873
Spaceflight, just like aging, causes profound changes in musculoskeletal parameters, which result in decreased bone density and muscular weakness. As these conditions decrease our ability to conduct long-term manned space...
20.
Semov A, Marcotte R, Semova N, Ye X, Wang E
Anal Biochem
. 2002 Feb;
302(1):38-51.
PMID: 11846374
An E-box (CACGTG) designer microarray was developed to monitor a group of genes whose expressions share a particular regulatory mode. Sensitivity and specificity of microarray hybridization, as well as variability...