Richard Marcellus
Overview
Explore the profile of Richard Marcellus including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
730
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Recent Articles
1.
CDC40 suppression induces CDCA5 splicing defects and anti-proliferative effects in lung cancer cells
Hu D, Theriault B, Talebian V, Hoffer L, Owen J, Lim J, et al.
Sci Rep
. 2025 Jan;
15(1):315.
PMID: 39747150
High mortality and low response rates in lung cancer patients call for novel therapeutic targets. Data mining of whole-genome genetic dependency screens suggest Cell Division Cycle 40 (CDC40) to be...
2.
Mabanglo M, Wilson B, Noureldin M, Kimani S, Mamai A, Krausser C, et al.
Nat Commun
. 2024 Nov;
15(1):10165.
PMID: 39580491
Proteolysis-targeting chimeras (PROTACs) have been explored for the degradation of drug targets for more than two decades. However, only a handful of E3 ligase substrate receptors have been efficiently used....
3.
Golbourn B, Ho B, Bondoc A, Luck A, Fan X, Richardson E, et al.
Neuro Oncol
. 2024 Jul;
26(10):1895-1911.
PMID: 38981018
Background: Atypical teratoid rhabdoid tumor (ATRT) is a rare, devastating, and largely incurable pediatric brain tumor. Although recent studies have uncovered 3 molecular subgroups of ATRTs with distinct disease patterns,...
4.
Su Y, Carter J, Li X, Fukuda Y, Gray A, Lynch J, et al.
Cancer Res
. 2024 Jan;
84(7):1084-1100.
PMID: 38266099
Significance: In AML cells, ONC213 suppresses αKGDH, which induces a unique mitochondrial stress response, and reduces MCL1 to decrease oxidative phosphorylation and elicit potent antileukemia activity. See related commentary by...
5.
Li A, Kimani S, Wilson B, Noureldin M, Gonzalez-Alvarez H, Mamai A, et al.
J Med Chem
. 2023 Mar;
66(7):5041-5060.
PMID: 36948210
DCAF1 is a substrate receptor of two distinct E3 ligases (CRL4 and EDVP), plays a critical physiological role in protein degradation, and is considered a drug target for various cancers....
6.
Mamai A, Chau A, Wilson B, Watson I, Joseph B, Subramanian P, et al.
ACS Med Chem Lett
. 2023 Feb;
14(2):199-210.
PMID: 36793435
B cell lymphoma 6 (BCL6), a highly regulated transcriptional repressor, is deregulated in several forms of non-Hodgkin lymphoma (NHL), most notably in diffuse large B-cell lymphoma (DLBCL). The activities of...
7.
Varney M, Steyaert W, Coucke P, Delanghe J, Uehling D, Joseph B, et al.
J Biol Chem
. 2022 Aug;
298(10):102421.
PMID: 36030052
Recent studies identified a missense mutation in the gene coding for G protein-coupled receptor kinase 6 (GRK6) that segregates with type 2 diabetes (T2D). To better understand how GRK6 might...
8.
Uehling D, Joseph B, Chung K, Zhang A, Ler S, Prakesch M, et al.
J Med Chem
. 2021 Dec;
65(1):886-887.
PMID: 34963044
No abstract available.
9.
Saraon P, Snider J, Schormann W, Rai A, Radulovich N, Sanchez-Osuna M, et al.
J Mol Biol
. 2021 Oct;
433(23):167294.
PMID: 34662547
Activating mutations in the epidermal growth factor receptor (EGFR) are common driver mutations in non-small cell lung cancer (NSCLC). First, second and third generation EGFR tyrosine kinase inhibitors (TKIs) are...
10.
Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival
Anderson N, Babichev Y, Fuligni F, Comitani F, Layeghifard M, Venier R, et al.
Nat Commun
. 2021 Jul;
12(1):4496.
PMID: 34301934
Leiomyosarcomas (LMS) are genetically heterogeneous tumors differentiating along smooth muscle lines. Currently, LMS treatment is not informed by molecular subtyping and is associated with highly variable survival. While disease site...