Gennady Poda
Overview
Explore the profile of Gennady Poda including associated specialties, affiliations and a list of published articles.
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27
Citations
317
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Recent Articles
1.
Peng H, Kotelnikov S, Egbert M, Ofaim S, Stevens G, Phanse S, et al.
Cell
. 2025 Jan;
188(5):1441-1455.e15.
PMID: 39862855
Knowledge of protein-metabolite interactions can enhance mechanistic understanding and chemical probing of biochemical processes, but the discovery of endogenous ligands remains challenging. Here, we combined rapid affinity purification with precision...
2.
Mabanglo M, Wilson B, Noureldin M, Kimani S, Mamai A, Krausser C, et al.
Nat Commun
. 2024 Nov;
15(1):10165.
PMID: 39580491
Proteolysis-targeting chimeras (PROTACs) have been explored for the degradation of drug targets for more than two decades. However, only a handful of E3 ligase substrate receptors have been efficiently used....
3.
Li F, Ackloo S, Arrowsmith C, Ban F, Barden C, Beck H, et al.
J Chem Inf Model
. 2024 Nov;
64(22):8521-8536.
PMID: 39499532
The CACHE challenges are a series of prospective benchmarking exercises to evaluate progress in the field of computational hit-finding. Here we report the results of the inaugural CACHE challenge in...
4.
Kotelnikov S, Ashizawa R, Popov K, Khan O, Ignatov M, Li S, et al.
Proteins
. 2023 Sep;
91(12):1822-1828.
PMID: 37697630
In the ligand prediction category of CASP15, the challenge was to predict the positions and conformations of small molecules binding to proteins that were provided as amino acid sequences or...
5.
Ignatov M, Jindal A, Kotelnikov S, Beglov D, Posternak G, Tang X, et al.
J Am Chem Soc
. 2023 Mar;
145(13):7123-7135.
PMID: 36961978
The design of PROteolysis-TArgeting Chimeras (PROTACs) requires bringing an E3 ligase into proximity with a target protein to modulate the concentration of the latter through its ubiquitination and degradation. Here,...
6.
Li A, Kimani S, Wilson B, Noureldin M, Gonzalez-Alvarez H, Mamai A, et al.
J Med Chem
. 2023 Mar;
66(7):5041-5060.
PMID: 36948210
DCAF1 is a substrate receptor of two distinct E3 ligases (CRL4 and EDVP), plays a critical physiological role in protein degradation, and is considered a drug target for various cancers....
7.
Mamai A, Chau A, Wilson B, Watson I, Joseph B, Subramanian P, et al.
ACS Med Chem Lett
. 2023 Feb;
14(2):199-210.
PMID: 36793435
B cell lymphoma 6 (BCL6), a highly regulated transcriptional repressor, is deregulated in several forms of non-Hodgkin lymphoma (NHL), most notably in diffuse large B-cell lymphoma (DLBCL). The activities of...
8.
Sohaei D, Hollenberg M, Janket S, Diamandis E, Poda G, Prassas I
Crit Rev Clin Lab Sci
. 2022 Aug;
60(1):25-40.
PMID: 35930434
While coronavirus disease 2019 (COVID-19) begins as a respiratory infection, it progresses as a systemic disease involving multiorgan microthromboses that underly the pathology. SARS-CoV-2 enters host cells attachment to the...
9.
Liu J, Sahin C, Ahmad S, Magomedova L, Zhang M, Jia Z, et al.
Sci Signal
. 2022 Jul;
15(741):eabo1857.
PMID: 35857636
The nuclear receptor peroxisome proliferator-activated receptor alpha (PPARα) is emerging as an important target in the brain for the treatment or prevention of cognitive disorders. The identification of high-affinity ligands...
10.
Sahin C, Magomedova L, Ferreira T, Liu J, Tiefenbach J, Alves P, et al.
J Med Chem
. 2022 Jan;
65(3):1961-1978.
PMID: 35089724
Metabolic diseases are increasing at staggering rates globally. The peroxisome proliferator-activated receptors (PPARα/γ/δ) are fatty acid sensors that help mitigate imbalances between energy uptake and utilization. Herein, we report compounds...