Richard Marcellus
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Explore the profile of Richard Marcellus including associated specialties, affiliations and a list of published articles.
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24
Citations
730
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Recent Articles
11.
Uehling D, Joseph B, Chung K, Zhang A, Ler S, Prakesch M, et al.
J Med Chem
. 2021 Jul;
64(15):11129-11147.
PMID: 34291633
Both previous and additional genetic knockdown studies reported herein implicate G protein-coupled receptor kinase 6 (GRK6) as a critical kinase required for the survival of multiple myeloma (MM) cells. Therefore,...
12.
Liang Y, Jeganathan S, Marastoni S, Sharp A, Figueiredo I, Marcellus R, et al.
Clin Cancer Res
. 2021 Feb;
27(8):2340-2351.
PMID: 33542074
Purpose: Although enzalutamide (ENZ) has been widely used to treat or castration-resistant metastatic prostate cancer, resistance develops and disease progression is ultimately inevitable. There are currently no approved targeted drugs...
13.
Saraon P, Snider J, Kalaidzidis Y, Wybenga-Groot L, Weiss K, Rai A, et al.
Nat Chem Biol
. 2020 Feb;
16(5):577-586.
PMID: 32094923
Receptor tyrosine kinases (RTKs) are transmembrane receptors of great clinical interest due to their role in disease. Historically, therapeutics targeting RTKs have been identified using in vitro kinase assays. Due...
14.
Baker A, Bahlmann L, Tam R, Liu J, Ganesh A, Mitrousis N, et al.
Adv Mater
. 2019 Jul;
31(36):e1901166.
PMID: 31322299
Many 3D in vitro models induce breast cancer spheroid formation; however, this alone does not recapitulate the complex in vivo phenotype. To effectively screen therapeutics, it is urgently needed to...
15.
Grinshtein N, Rioseco C, Marcellus R, Uehling D, Aman A, Lun X, et al.
Oncotarget
. 2016 Jul;
7(37):59360-59376.
PMID: 27449082
Glioblastoma (GBM) is the most lethal and aggressive adult brain tumor, requiring the development of efficacious therapeutics. Towards this goal, we screened five genetically distinct patient-derived brain-tumor initiating cell lines...
16.
Getlik M, Smil D, Zepeda-Velazquez C, Bolshan Y, Poda G, Wu H, et al.
J Med Chem
. 2016 Mar;
59(6):2478-96.
PMID: 26958703
WD repeat-containing protein 5 (WDR5) is an important component of the multiprotein complex essential for activating mixed-lineage leukemia 1 (MLL1). Rearrangement of the MLL1 gene is associated with onset and...
17.
Braunstein M, Liao L, Lyttle N, Lobo N, Taylor K, Krzyzanowski P, et al.
Breast Cancer Res
. 2016 Feb;
18(1):16.
PMID: 26852132
Background: Drug resistance in breast cancer is the major obstacle to effective treatment with chemotherapy. While upregulation of multidrug resistance genes is an important component of drug resistance mechanisms in...
18.
Grebien F, Vedadi M, Getlik M, Giambruno R, Grover A, Avellino R, et al.
Nat Chem Biol
. 2015 Sep;
11(10):815.
PMID: 26379026
No abstract available.
19.
Grebien F, Vedadi M, Getlik M, Giambruno R, Grover A, Avellino R, et al.
Nat Chem Biol
. 2015 Jul;
11(8):571-578.
PMID: 26167872
The CEBPA gene is mutated in 9% of patients with acute myeloid leukemia (AML). Selective expression of a short (30-kDa) CCAAT-enhancer binding protein-α (C/EBPα) translational isoform, termed p30, represents the...
20.
Barsyte-Lovejoy D, Li F, Oudhoff M, Tatlock J, Dong A, Zeng H, et al.
Proc Natl Acad Sci U S A
. 2014 Aug;
111(35):12853-8.
PMID: 25136132
SET domain containing (lysine methyltransferase) 7 (SETD7) is implicated in multiple signaling and disease related pathways with a broad diversity of reported substrates. Here, we report the discovery of (R)-PFI-2-a...