Richard M Weinshilboum
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Explore the profile of Richard M Weinshilboum including associated specialties, affiliations and a list of published articles.
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204
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5171
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Recent Articles
1.
Safgren S, Suman V, Leon Ferre R, Kosel M, Stearns V, Henry N, et al.
Breast Cancer Res Treat
. 2025 Feb;
PMID: 40011368
Purpose: Tamoxifen undergoes metabolic activation by cytochrome P450 (CYP) enzymes to metabolites with more potent anti-estrogenic effects. Numerous studies demonstrate decreased tamoxifen efficacy associated with reduced CYP2D6 activity or lower...
2.
Huang M, Qin S, Gao H, Kim W, Xie F, Yin P, et al.
Cells
. 2024 Oct;
13(19.
PMID: 39404386
Most patients with metastatic prostate cancer eventually develop resistance to primary androgen deprivation therapy. To identify predictive biomarker for Abiraterone acetate/prednisone resistance, we screened alternative splice variants between responders and...
3.
Gao H, Wei L, Indulkar S, Nguyen T, Liu D, Ho M, et al.
Breast Cancer Res
. 2024 Jul;
26(1):111.
PMID: 38965614
Background: Endocrine therapy is the most important treatment modality of breast cancer patients whose tumors express the estrogen receptor α (ERα). The androgen receptor (AR) is also expressed in the...
4.
Ho M, Zhang C, Cohan J, Tuncturk M, Heider R, Coombes B, et al.
Brain Behav Immun
. 2024 Jun;
120():304-314.
PMID: 38852760
Acamprosate is a Food and Drug Administration (FDA) approved medication for the treatment of alcohol use disorder (AUD). However, only a subset of patients achieves optimal treatment outcomes. Currently, no...
5.
Tang X, Prodduturi N, Thompson K, Weinshilboum R, OSullivan C, Boughey J, et al.
bioRxiv
. 2024 Apr;
PMID: 38585820
The OmicsFootPrint framework addresses the need for advanced multi-omics data analysis methodologies by transforming data into intuitive two-dimensional circular images and facilitating the interpretation of complex diseases. Utilizing Deep Neural...
6.
Sanchez-Ruiz J, Leibman N, Larson N, Jenkins G, Ahmed A, Nunez N, et al.
J Womens Health (Larchmt)
. 2023 Oct;
32(11):1229-1240.
PMID: 37856151
Antidepressants are among the most prescribed medications in the United States. The aim of this study was to explore the prevalence of antidepressant prescriptions and investigate sex differences and age-sex...
7.
Liu D, Wang M, Murthy V, McNamara D, Nguyen T, Philips T, et al.
Circ Res
. 2023 Oct;
133(10):810-825.
PMID: 37800334
Background: Dilated cardiomyopathy (DCM) is a major cause of heart failure and carries a high mortality rate. Myocardial recovery in DCM-related heart failure patients is highly variable, with some patients...
8.
Ho M, Zhang C, Moon I, Biernacka J, Coombes B, Ngo Q, et al.
Mol Metab
. 2023 Sep;
77:101798.
PMID: 37689244
Objective: Fibroblast growth factor 21 (FGF21) analogs have been tested as potential therapeutics for substance use disorders. Prior research suggests that FGF21 administration might affect alcohol consumption and reward behaviors....
9.
Lewis A, Costello B, Quevedo F, Pagliaro L, Sanhueza C, Weinshilboum R, et al.
Prostate
. 2023 Mar;
83(7):649-655.
PMID: 36924119
Objective: Elevated serum chromogranin A (CGA) is associated with intrinsic or treatment-related neuroendocrine differentiation (NED) in men with metastatic castration-resistant prostate cancer (mCRPC). Fluctuations in serum CGA during treatment of...
10.
Zhang H, Gao H, Gu Y, John A, Wei L, Huang M, et al.
Front Oncol
. 2022 Dec;
12:999302.
PMID: 36523978
Poly(ADP-ribose) (PAR) polymerase inhibitors (PARPi) either have been approved or being tested in the clinic for the treatment of a variety of cancers with homologous recombination deficiency (HRD). However, cancer...