Richard M Ogborne
Overview
Explore the profile of Richard M Ogborne including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
251
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0
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Recent Articles
1.
Ogborne R, Rushworth S, OConnell M
Biochem Biophys Res Commun
. 2008 Jul;
373(4):584-8.
PMID: 18586007
The Nrf2/anti-oxidant response element (ARE) pathway plays an important role in regulating cellular anti-oxidants, including haem oxygenase-1 (HO-1). Various kinases have been implicated in the pathways leading to Nrf2 activation....
2.
Ginger R, Askew S, Ogborne R, Wilson S, Ferdinando D, Dadd T, et al.
J Biol Chem
. 2008 Jan;
283(9):5486-95.
PMID: 18166528
A non-synonymous single nucleotide polymorphism in the human SLC24A5 gene is associated with natural human skin color variation. Multiple sequence alignments predict that this gene encodes a member of the...
3.
Talbot D, Ogborne R, Dadd T, Adlercreutz H, Barnard G, Bugel S, et al.
Clin Chem
. 2007 Feb;
53(4):748-56.
PMID: 17317887
Background: Time-resolved fluorescence immunoassays (TR-FIAs) for phytoestrogens in biological samples are an alternative to mass spectrometric methods. These immunoassays were used to test urine and plasma samples from individuals in...
4.
Rushworth S, Ogborne R, Charalambos C, OConnell M
Biochem Biophys Res Commun
. 2006 Feb;
341(4):1007-16.
PMID: 16460683
The Nrf2/antioxidant response element (ARE) signaling pathway plays a key role in activating cellular antioxidants, including heme oxygenase-1 (HO-1), NADPH quinone oxidoreductase-1 (NQO1), and glutathione. Protein kinase C (PKC) may...
5.
Rushworth S, Chen X, Mackman N, Ogborne R, OConnell M
J Immunol
. 2005 Sep;
175(7):4408-15.
PMID: 16177082
Monocytes play a key role in mobilization of the immune response during sepsis. In response to LPS, monocytes produce both proinflammatory mediators and regulatory proteins that counteract the inflammation and...
6.
Ogborne R, Rushworth S, OConnell M
Arterioscler Thromb Vasc Biol
. 2005 Aug;
25(10):2100-5.
PMID: 16123320
Objective: Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme catabolism, plays a protective role in the vascular system. HO-1 induction inhibits cytokine production in macrophages. Antioxidants induce HO-1 expression in...