Richard M Giadone
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Explore the profile of Richard M Giadone including associated specialties, affiliations and a list of published articles.
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14
Citations
76
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Recent Articles
1.
Ximerakis M, Holton K, Giadone R, Ozek C, Saxena M, Santiago S, et al.
Nat Aging
. 2025 Jan;
5(2):333.
PMID: 39881191
No abstract available.
2.
Dowrey T, Cranston S, Skvir N, Lok Y, Gould B, Petrowitz B, et al.
Aging Cell
. 2024 Sep;
24(1):e14351.
PMID: 39319670
Centenarians provide a unique lens through which to study longevity, healthy aging, and resiliency. Moreover, models of human aging and resilience to disease that allow for the testing of potential...
3.
Leow D, Ng Y, Wang L, Koh H, Zhao T, Khong Z, et al.
J Clin Invest
. 2024 May;
134(12).
PMID: 38722695
Spinal muscular atrophy (SMA) is typically characterized as a motor neuron disease, but extraneuronal phenotypes are present in almost every organ in severely affected patients and animal models. Extraneuronal phenotypes...
4.
Dowrey T, Cranston S, Skvir N, Lok Y, Gould B, Petrowitz B, et al.
bioRxiv
. 2024 Apr;
PMID: 38559230
Centenarians provide a unique lens through which to study longevity, healthy aging, and resiliency. Moreover, models of aging and resilience to disease that allow for the testing of potential interventions...
5.
Edwards C, Ferri G, Villegas-Galaviz J, Ghosh S, Bawa P, Wang F, et al.
bioRxiv
. 2024 Apr;
PMID: 38558967
Background: Cardiac dysfunction in AL amyloidosis is thought to be partly related to the direct impact of AL LCs on cardiomyocyte function, with the degree of dysfunction at diagnosis as...
6.
Watts M, Giadone R, Ordureau A, Holton K, Harper J, Rubin L
Front Cell Neurosci
. 2024 Feb;
17:1327361.
PMID: 38314348
Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron (MN) disease with severely limited treatment options. Identification of effective treatments has been limited in part by the lack of predictive...
7.
Holton K, Giadone R, Lang B, Calderwood S
Methods Mol Biol
. 2023 Aug;
2693:39-60.
PMID: 37540425
RNA sequencing (RNA-seq) is a powerful method of transcriptional analysis that allows for the sequence identification and quantification of cellular transcripts. RNA-seq can be used for differential gene expression (DGE)...
8.
Ghosh S, Villacorta-Martin C, Lindstrom-Vautrin J, Kenney D, Golden C, Edwards C, et al.
Amyloid
. 2023 Jul;
30(4):379-393.
PMID: 37439769
Background: In ATTR amyloidosis, transthyretin (TTR) protein is secreted from the liver and deposited as toxic aggregates at downstream target tissues. Despite recent advancements in treatments for ATTR amyloidosis, the...
9.
Ximerakis M, Holton K, Giadone R, Ozek C, Saxena M, Santiago S, et al.
Nat Aging
. 2023 Apr;
3(3):327-345.
PMID: 37118429
Aging is a complex process involving transcriptomic changes associated with deterioration across multiple tissues and organs, including the brain. Recent studies using heterochronic parabiosis have shown that various aspects of...
10.
Neel D, Basu H, Gunner G, Bergstresser M, Giadone R, Chung H, et al.
Neuron
. 2023 Mar;
111(8):1222-1240.e9.
PMID: 36917977
Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin (GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their roles in the central nervous system (CNS)...