Ian S Roberts
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Explore the profile of Ian S Roberts including associated specialties, affiliations and a list of published articles.
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66
Citations
2090
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Recent Articles
1.
Layton E, Goldsworthy S, Yang E, Ong W, Sutherland T, Bancroft A, et al.
Nat Commun
. 2025 Feb;
16(1):1589.
PMID: 39939598
The intestine is a site of diverse functions including digestion, nutrient absorption, immune surveillance, and microbial symbiosis. Intestinal microRNAs (miRNAs) are detectable in faeces and regulate barrier integrity, host-microbe interactions...
2.
McCallion O, Cross A, Brook M, Hennessy C, Ferreira R, Trzupek D, et al.
Med
. 2024 Dec;
:100561.
PMID: 39731908
Background: Adoptive transfer of autologous regulatory T cells (Tregs) is a promising therapeutic strategy aimed at enabling immunosuppression minimization following kidney transplantation. In our phase 1 clinical trial of Treg...
3.
Alnakhli L, Goldrick M, Lord E, Roberts I
Microbiology (Reading)
. 2024 Nov;
170(11).
PMID: 39560979
is a food-borne pathogen that must adapt to several environments both inside and outside the host. One such environment is the microaerophilic conditions encountered in the host intestine proximal to...
4.
Dubaissi E, Hilton E, Lilley S, Collins R, Holt C, March P, et al.
Sci Rep
. 2024 Oct;
14(1):25555.
PMID: 39461969
The TMEM16A chloride channel is proposed as a therapeutic target in cystic fibrosis, where activation of this ion channel might restore airway surface hydration and mitigate respiratory symptoms. While TMEM16A...
5.
Feltham L, Moran J, Goldrick M, Lord E, Spiller D, Cavet J, et al.
Front Cell Infect Microbiol
. 2024 Jul;
14:1411124.
PMID: 39045131
Dissemination of food-borne in the host relies on internalin-mediated invasion, but the underlying invasion strategies remain elusive. Here we use live-cell microscopy to follow single cell interactions between individual human...
6.
Carneiro da Cunha Martorelli V, Akabuogu E, Krasovec R, Roberts I, Waigh T
Phys Rev E
. 2024 Jun;
109(5-1):054402.
PMID: 38907459
Agent-based models were used to describe electrical signaling in bacterial biofilms in three dimensions. Specifically, wavefronts of potassium ions in Escherichia coli biofilms subjected to stress from blue light were...
7.
Akabuogu E, Zhang L, Krasovec R, Roberts I, Waigh T
Nano Lett
. 2024 Feb;
24(7):2234-2241.
PMID: 38320294
Negative capacitance at low frequencies for spiking neurons was first demonstrated in 1941 (K. S. Cole) by using extracellular electrodes. The phenomenon subsequently was explained by using the Hodgkin-Huxley model...
8.
Bay O, Hayes K, Schwartz J, Grencis R, Roberts I
Nat Commun
. 2023 Nov;
14(1):6937.
PMID: 37907472
Genome-scale metabolic models are widely used to enhance our understanding of metabolic features of organisms, host-pathogen interactions and to identify therapeutics for diseases. Here we present iTMU798, the genome-scale metabolic...
9.
Aldawood E, Roberts I
Front Microbiol
. 2022 Apr;
13:858767.
PMID: 35359738
The expression of a group 2 capsule (K antigen), such as the K1 or K5 antigen, is a key virulence factor of responsible for extra-intestinal infections. Capsule expression confers resistance...
10.
Lawson M, Roberts I, Grencis R
Parasitology
. 2021 Jun;
:1-8.
PMID: 34075861
Parasitic worms are amongst the most common pathogens to infect humans and have a long-established history of inflicting disease in their hosts. There is a large body of evidence that...