Richard K Gessner
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Explore the profile of Richard K Gessner including associated specialties, affiliations and a list of published articles.
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5
Citations
69
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Recent Articles
1.
Sousa B, Mottin M, Seanego D, Jurisch C, Rodrigues B, da Silva V, et al.
ACS Med Chem Lett
. 2024 Dec;
15(12):2140-2149.
PMID: 39691531
The SARS-CoV-2 pandemic has significantly challenged global public health, highlighting the need for effective therapeutic options. This study focuses on the papain-like protease (PLpro) of SARS-CoV-2, which is a critical...
2.
Wilson C, Gessner R, Moosa A, Seldon R, Warner D, Mizrahi V, et al.
J Med Chem
. 2017 Nov;
60(24):10118-10134.
PMID: 29148755
A BioFocus DPI SoftFocus library of ∼35 000 compounds was screened against Mycobacterium tuberculosis (Mtb) in order to identify novel hits with antitubercular activity. The hits were evaluated in biology...
3.
van der Westhuyzen R, Winks S, Wilson C, Boyle G, Gessner R, Soares de Melo C, et al.
J Med Chem
. 2015 Nov;
58(23):9371-81.
PMID: 26551248
High-throughput screening of a library of small polar molecules against Mycobacterium tuberculosis led to the identification of a phthalimide-containing ester hit compound (1), which was optimized for metabolic stability by...
4.
Soares de Melo C, Candice S, Feng T, van der Westhuyzen R, Gessner R, Street L, et al.
Bioorg Med Chem
. 2015 Nov;
23(22):7240-50.
PMID: 26522089
Whole-cell high-throughput screening of a diverse SoftFocus library against Mycobacterium tuberculosis (Mtb) generated a novel aminopyrazolo[1,5-a]pyrimidine hit series. The synthesis and structure activity relationship studies identified compounds with potent antimycobacterial...
5.
Ndakala A, Gessner R, Gitari P, October N, White K, Hudson A, et al.
J Med Chem
. 2011 Jun;
54(13):4581-9.
PMID: 21644541
A novel class of antimalarial pyrido[1,2-a]benzimidazoles were synthesized and evaluated for antiplasmodial activity and cytotoxicity following hits identified from screening commercially available compound collections. The most active of these, TDR86919...