Candice Soares de Melo
Overview
Explore the profile of Candice Soares de Melo including associated specialties, affiliations and a list of published articles.
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7
Citations
88
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Recent Articles
1.
Woodland J, Horatscheck A, Soares de Melo C, Dziwornu G, Taylor D
Prog Med Chem
. 2024 Oct;
63(1):161-234.
PMID: 39370241
Malaria remains a devastating but preventable infectious disease that disproportionately affects the African continent. Emerging resistance to current frontline therapies means that not only are new treatments urgently required, but...
2.
Soares de Melo C, Singh V, Myrick A, Simelane S, Taylor D, Brunschwig C, et al.
J Med Chem
. 2021 Jan;
64(1):719-740.
PMID: 33395287
Phenotypic screening of a Medicines for Malaria Venture compound library against () identified a cluster of pan-active 2-pyrazolylpyrimidinones. The biology triage of these actives using various tool strains of suggested...
3.
Martinez-Grau M, Gonzalez Valcarcel I, Early J, Gessner R, Soares de Melo C, de la Nava E, et al.
Bioorg Med Chem Lett
. 2018 Apr;
28(10):1758-1764.
PMID: 29680666
Despite increased research efforts to find new treatments for tuberculosis in recent decades, compounds with novel mechanisms of action are still required. We previously identified a series of novel aryl-oxadiazoles...
4.
Murugesan D, Ray P, Bayliss T, Prosser G, Harrison J, Green K, et al.
ACS Infect Dis
. 2018 Mar;
4(6):954-969.
PMID: 29522317
Mycobacterium tuberculosis ( MTb) possesses two nonproton pumping type II NADH dehydrogenase (NDH-2) enzymes which are predicted to be jointly essential for respiratory metabolism. Furthermore, the structure of a closely...
5.
Wilson C, Gessner R, Moosa A, Seldon R, Warner D, Mizrahi V, et al.
J Med Chem
. 2017 Nov;
60(24):10118-10134.
PMID: 29148755
A BioFocus DPI SoftFocus library of ∼35 000 compounds was screened against Mycobacterium tuberculosis (Mtb) in order to identify novel hits with antitubercular activity. The hits were evaluated in biology...
6.
van der Westhuyzen R, Winks S, Wilson C, Boyle G, Gessner R, Soares de Melo C, et al.
J Med Chem
. 2015 Nov;
58(23):9371-81.
PMID: 26551248
High-throughput screening of a library of small polar molecules against Mycobacterium tuberculosis led to the identification of a phthalimide-containing ester hit compound (1), which was optimized for metabolic stability by...
7.
Soares de Melo C, Candice S, Feng T, van der Westhuyzen R, Gessner R, Street L, et al.
Bioorg Med Chem
. 2015 Nov;
23(22):7240-50.
PMID: 26522089
Whole-cell high-throughput screening of a diverse SoftFocus library against Mycobacterium tuberculosis (Mtb) generated a novel aminopyrazolo[1,5-a]pyrimidine hit series. The synthesis and structure activity relationship studies identified compounds with potent antimycobacterial...