Richard J Stratton
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Explore the profile of Richard J Stratton including associated specialties, affiliations and a list of published articles.
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Recent Articles
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Naik A, Stratton R, Leask A
Wound Repair Regen
. 2024 Sep;
32(6):949-959.
PMID: 39323322
Scleroderma or systemic sclerosis (SSc)-associated digital ischaemic complications, such as digital ulcers (SSc-DUs), appear relatively early during the disease course and are a major burden with substantial deterioration of quality...
3.
Leask A, Naik A, Stratton R
Nat Rev Rheumatol
. 2023 Oct;
19(11):713-723.
PMID: 37789119
Fibrosis is the excessive deposition of a stable extracellular matrix (ECM); fibrotic tissue is composed principally of highly crosslinked type I collagen and highly contractile myofibroblasts. Systemic sclerosis (SSc) is...
4.
Chitturi P, Xu S, Ahmed Abdi B, Nguyen J, Carter D, Sinha S, et al.
Ann Rheum Dis
. 2023 Jun;
82(9):1191-1204.
PMID: 37328193
Objectives: Systemic sclerosis (SSc) is characterised by extensive tissue fibrosis maintained by mechanotranductive/proadhesive signalling. Drugs targeting this pathway are therefore of likely therapeutic benefit. The mechanosensitive transcriptional co-activator, yes activated...
5.
Quesnel K, Shi-Wen X, Hutchenreuther J, Xiao Y, Liu S, Peidl A, et al.
Matrix Biol Plus
. 2021 Feb;
3:100009.
PMID: 33543008
The microenvironment contributes to the excessive connective tissue deposition that characterizes fibrosis. Members of the CCN family of matricellular proteins are secreted by fibroblasts into the fibrotic microenvironment; however, the...
6.
Shi-Wen X, Racanelli M, Ali A, Simon A, Quesnel K, Stratton R, et al.
J Cell Commun Signal
. 2021 Jan;
15(1):71-80.
PMID: 33398723
Fibrosis is perpetuated by an autocrine, pro-adhesive signaling loop maintained by the synthetic and contractile abilities of myofibroblasts and the stiff, highly-crosslinked extracellular matrix. Transcriptional complexes that are exquisitely responsive...
7.
Murphy-Marshman H, Quensel K, Shi-Wen X, Barnfield R, Kelly J, Peidl A, et al.
PLoS One
. 2017 Oct;
12(10):e0186740.
PMID: 29049376
TGFbeta induces fibrogenic responses in fibroblasts. Reactive oxygen species (ROS)/nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) may contribute to fibrogenic responses. Here, we examine if the antioxidant N-acetylcysteine (NAC), the...
8.
Clark K, Lopez H, Ahmed Abdi B, Guerra S, Shiwen X, Khan K, et al.
Arthritis Res Ther
. 2015 Apr;
17:73.
PMID: 25885360
Introduction: Clinical diversity in systemic sclerosis (SSc) reflects multifaceted pathogenesis and the effect of key growth factors or cytokines operating within a disease-specific microenvironment. Dermal interstitial fluid sampling offers the...
9.
Aden N, Nuttall A, Shiwen X, de Winter P, Leask A, Black C, et al.
J Invest Dermatol
. 2010 May;
130(9):2191-200.
PMID: 20445556
Systemic sclerosis (SSc) is a disorder of systemic and dermal fibrosis of uncertain etiology. Recently, we found that SSc epidermis is abnormal, taking on an activated phenotype observed during wound...
10.
Shi-Wen X, Eastwood M, Stratton R, Denton C, Leask A, Abraham D
Rheumatology (Oxford)
. 2009 Dec;
49(2):259-63.
PMID: 20007285
Objective: The transcription factor peroxisome proliferator-activated receptor (PPAR)-gamma plays an important role in controlling cell differentiation. The aim of the present study was to examine whether PPAR-gamma expression was reduced...