Richard G Gardner
Overview
Explore the profile of Richard G Gardner including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
39
Citations
1096
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0
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Recent Articles
1.
Mashahreh B, Armony S, Johansson K, Chappleboim A, Friedman N, Gardner R, et al.
Nat Commun
. 2022 Dec;
13(1):7588.
PMID: 36481666
The eukaryotic proteome undergoes constant surveillance by quality control systems that either sequester, refold, or eliminate aberrant proteins by ubiquitin-dependent mechanisms. Ubiquitin-conjugation necessitates the recognition of degradation determinants, termed degrons,...
2.
Ibarra R, Borror H, Hart B, Gardner R, Kleiger G
Biomolecules
. 2021 Nov;
11(11).
PMID: 34827617
Cellular homeostasis depends on robust protein quality control (PQC) pathways that discern misfolded proteins from functional ones in the cell. One major branch of PQC involves the controlled degradation of...
3.
Bradley A, Marsh N, Borror H, Mostoller K, Gama A, Gardner R
Mol Biol Cell
. 2021 Mar;
32(11):1121-1133.
PMID: 33788582
Stress is ubiquitous to life and can irreparably damage essential biomolecules and organelles in cells. To survive, organisms must sense and adapt to stressful conditions. One highly conserved adaptive stress...
4.
Jones R, Enam C, Ibarra R, Borror H, Mostoller K, Fredrickson E, et al.
Mol Biol Cell
. 2019 Dec;
31(3):221-233.
PMID: 31825716
Protein misfolding is a recurring phenomenon that cells must manage; otherwise misfolded proteins can aggregate and become toxic should they persist. To counter this burden, cells have evolved protein quality...
5.
Nadel C, Mackie T, Gardner R
PLoS Genet
. 2019 Apr;
15(4):e1008115.
PMID: 31009461
Environmental stressors can severely perturb cellular homeostasis and compromise viability. To cope with environmental stressors, eukaryotes have developed distinct signaling programs that allow for adaptation during different stress conditions. These...
6.
Geffen Y, Appleboim A, Gardner R, Ravid T
Methods Mol Biol
. 2018 Sep;
1844:121-136.
PMID: 30242707
Since its discovery nearly 40 years ago, many components of the ubiquitin-proteasome system (UPS) have been identified and characterized in detail. However, a key aspect of the UPS that remains...
7.
Gardner R, Ravid T
Mol Cell
. 2018 Jun;
70(6):989-990.
PMID: 29932909
In the current issue of Molecular Cell, Szoradi et al. (2018) present compelling data demonstrating how the newly identified SHRED pathway in yeast selectively shifts the E3 ligase Ubr1 specificity...
8.
Enam C, Geffen Y, Ravid T, Gardner R
Annu Rev Biochem
. 2018 Jun;
87:725-749.
PMID: 29925261
Nuclear proteins participate in diverse cellular processes, many of which are essential for cell survival and viability. To maintain optimal nuclear physiology, the cell employs the ubiquitin-proteasome system to eliminate...
9.
Cao J, Detloff P, Gardner R, Stella N
Behav Brain Res
. 2017 Sep;
337:34-45.
PMID: 28927719
Huntington's Disease (HD) is an autosomal dominant neurodegenerative disease characterized by gradual deterioration of motor and cognitive functions and development of psychiatric deficits. Animal models provide powerful means to study...
10.
Swider B, Liu J, Harris T, Gardner R
J Appl Psychol
. 2017 Mar;
102(6):890-909.
PMID: 28277728
As employee careers have evolved from linear trajectories confined within 1 organization to more dynamic and boundaryless paths, organizations and individuals alike have increasingly considered reestablishing prior employment relationships. These...