Richard G Brennan
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Explore the profile of Richard G Brennan including associated specialties, affiliations and a list of published articles.
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92
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3855
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Recent Articles
11.
Beggs G, Ayala J, Kavanaugh L, Read T, Hooks G, Schumacher M, et al.
Nucleic Acids Res
. 2021 Mar;
49(7):4155-4170.
PMID: 33784401
Mutations within the mtrR gene are commonly found amongst multidrug resistant clinical isolates of Neisseria gonorrhoeae, which has been labelled a superbug by the Centers for Disease Control and Prevention....
12.
Travis B, Ramsey K, Prezioso S, Tallo T, Wandzilak J, Hsu A, et al.
Mol Cell
. 2020 Nov;
81(1):139-152.e10.
PMID: 33217319
The bacterium Francisella tularensis (Ft) is one of the most infectious agents known. Ft virulence is controlled by a unique combination of transcription regulators: the MglA-SspA heterodimer, PigR, and the...
13.
Arshad M, Beggs G, Brennan R, Seed P
Antimicrob Agents Chemother
. 2020 Oct;
65(1).
PMID: 33077659
We previously identified a small-molecule inhibitor of capsule biogenesis (designated DU011) and identified its target as MprA, a MarR family transcriptional repressor of multidrug efflux pumps. Unlike other proposed MprA...
14.
Orans J, Kovach A, Hoff K, Horstmann N, Brennan R
Nucleic Acids Res
. 2020 Mar;
48(7):3987-3997.
PMID: 32133526
Hfq regulates bacterial gene expression post-transcriptionally by binding small RNAs and their target mRNAs, facilitating sRNA-mRNA annealing, typically resulting in translation inhibition and RNA turnover. Hfq is also found in...
15.
Dorman C, Schumacher M, Bush M, Brennan R, Buttner M
Curr Opin Microbiol
. 2020 Mar;
55:26-33.
PMID: 32120333
Proteins that regulate transcription often also play an architectural role in the genome. Thus, it has been difficult to define with precision the distinctions between transcription factors and nucleoid-associated proteins...
16.
Gibbs K, Washington E, Jaslow S, Bourgeois J, Foster M, Guo R, et al.
Cell Host Microbe
. 2020 Jan;
27(1):129-139.e4.
PMID: 31901521
Bacteria masterfully co-opt and subvert host signal transduction. As a paradigmatic example, Salmonella uses two type-3 secretion systems to inject effector proteins that facilitate Salmonella entry, establishment of an intracellular...
17.
Gallagher K, Schumacher M, Bush M, Bibb M, Chandra G, Holmes N, et al.
Mol Cell
. 2019 Dec;
77(3):586-599.e6.
PMID: 31810759
Streptomyces are our primary source of antibiotics, produced concomitantly with the transition from vegetative growth to sporulation in a complex developmental life cycle. We previously showed that the signaling molecule...
18.
Beggs G, Brennan R, Arshad M
Protein Sci
. 2019 Nov;
29(3):647-653.
PMID: 31682303
There has been a rapid spread of multidrug-resistant (MDR) bacteria across the world. MDR efflux transporters are an important mechanism of antibiotic resistance in many pathogens among both Gram positive...
19.
Beggs G, Zalucki Y, Brown N, Rastegari S, Phillips R, Palzkill T, et al.
J Bacteriol
. 2019 Jul;
201(20).
PMID: 31331979
responds to host-derived antimicrobials by inducing the expression of the -encoded multidrug efflux pump, which expels microbicides, such as bile salts, fatty acids, and multiple extrinsically administered drugs, from the...
20.
Claeys H, Vi S, Xu X, Satoh-Nagasawa N, Eveland A, Goldshmidt A, et al.
Nat Plants
. 2019 Apr;
5(4):352-357.
PMID: 30936436
Meristem fate is regulated by trehalose 6-phosphate phosphatases (TPPs), but their mechanism of action remains mysterious. Loss of the maize TPPs RAMOSA3 and TPP4 leads to reduced meristem determinacy and...