Richard Daneman
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Explore the profile of Richard Daneman including associated specialties, affiliations and a list of published articles.
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62
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Recent Articles
1.
Lawrence J, Patel A, King M, Nadarajah C, Daneman R, Musiek E
JCI Insight
. 2024 Nov;
9(21).
PMID: 39513366
The blood-brain barrier (BBB) is critical for maintaining brain homeostasis but is susceptible to inflammatory dysfunction. While transporter-dependent efflux of some lipophilic substrates across the BBB shows circadian variation due...
2.
Profaci C, Harvey S, Bajc K, Zhang T, Jeffrey D, Zhang A, et al.
Neuron
. 2024 Aug;
112(17):2910-2921.e7.
PMID: 39142282
Microglia, the resident immune cells of the central nervous system, are intimately involved in the brain's most basic processes, from pruning neural synapses during development to preventing excessive neuronal activity...
3.
Frias-Anaya E, Gallego-Gutierrez H, Gongol B, Weinsheimer S, Lai C, Orecchioni M, et al.
Arterioscler Thromb Vasc Biol
. 2024 Apr;
44(6):1246-1264.
PMID: 38660801
Background: Heterogeneity in the severity of cerebral cavernous malformations (CCMs) disease, including brain bleedings and thrombosis that cause neurological disabilities in patients, suggests that environmental, genetic, or biological factors act...
4.
Lawrence J, Patel A, King M, Nadarajah C, Daneman R, Musiek E
bioRxiv
. 2024 Apr;
PMID: 38645230
The blood-brain barrier (BBB) is critical for maintaining brain homeostasis but is susceptible to inflammatory dysfunction. Permeability of the BBB to lipophilic molecules shows circadian variation due to rhythmic transporter...
5.
Gastfriend B, Snyder M, Holt H, Daneman R, Palecek S, Shusta E
Sci Adv
. 2024 Feb;
10(5):eadi1737.
PMID: 38306433
Brain mural cells regulate development and function of the blood-brain barrier and control blood flow. Existing in vitro models of human brain mural cells have low expression of key mural...
6.
Lummis N, Gastfriend B, Daneman R
J Exp Med
. 2024 Jan;
221(2).
PMID: 38270593
Mural cells directly contact macrophages in the dural layer of the meninges to suppress pro-inflammatory phenotypes, including antigen presentation and lymphocyte differentiation. These mechanisms represent new targets for modulating CNS...
7.
Chew K, Wells R, Moshkforoush A, Chan D, Lechtenberg K, Tran H, et al.
Nat Commun
. 2023 Sep;
14(1):5516.
PMID: 37679403
No abstract available.
8.
Chew K, Wells R, Moshkforoush A, Chan D, Lechtenberg K, Tran H, et al.
Nat Commun
. 2023 Aug;
14(1):5053.
PMID: 37598178
Brain exposure of systemically administered biotherapeutics is highly restricted by the blood-brain barrier (BBB). Here, we report the engineering and characterization of a BBB transport vehicle targeting the CD98 heavy...
9.
Shoemaker L, Daneman R, Stoodley M
Front Hum Neurosci
. 2023 Jun;
17:1212184.
PMID: 37351364
No abstract available.
10.
Ma Y, Sannino D, Linden J, Haigh S, Zhao B, Grigg J, et al.
J Clin Invest
. 2023 Feb;
133(9).
PMID: 36853799
Multiple sclerosis (MS) is a complex disease of the CNS thought to require an environmental trigger. Gut dysbiosis is common in MS, but specific causative species are unknown. To address...