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Richard Bucala

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Articles 388
Citations 14079
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Recent Articles
1.
El Bounkari O, Zan C, Yang B, Ebert S, Wagner J, Bugar E, et al.
Nat Commun . 2025 Mar; 16(1):2297. PMID: 40055309
Atherosclerosis is the underlying cause of myocardial infarction and ischemic stroke. It is a lipid-triggered and cytokine/chemokine-driven arterial inflammatory condition. We identify D-dopachrome tautomerase/macrophage migration-inhibitory factor-2 (MIF-2), a paralog of...
2.
Sanchez-Zuno G, Bucala R, Hernandez-Bello J, Palafox-Sanchez C, Vizcaino-Quirarte A, Munoz-Valle J
J Interferon Cytokine Res . 2025 Feb; 45(3):99-106. PMID: 39914814
We previously reported the peripheral blood cell patterns of expression for the migration inhibitory factor (MIF) canonical (CD74/CD44) and noncanonical receptors (CXCR2, CXCR4, and CXCR7) in rheumatoid arthritis (RA) patients...
3.
Shin J, Shin H, Gutierrez A, Yoo N, Par-Young J, Osmani L, et al.
EBioMedicine . 2025 Feb; 112:105578. PMID: 39891996
Background: The 17q12 deletion syndrome (17q12DS) is a heterozygous deletion of a 1.4 megabase‒spanning DNA sequence on chromosome 17. The clinical characteristics of 17q12DS include neurodevelopmental disorders, kidney and urinary...
4.
Pellegrino B, David K, Rabani S, Lampert B, Tran T, Doherty E, et al.
PLoS Biol . 2024 Nov; 22(11):e3002905. PMID: 39576827
CD74 is a cell-surface receptor for the cytokine macrophage migration inhibitory factor (MIF). MIF binding to CD74 induces a signaling cascade resulting in the release of its cytosolic intracellular domain...
5.
Jarmula J, Lee J, Lauko A, Rajappa P, Grabowski M, Dhawan A, et al.
Neurooncol Adv . 2024 Sep; 6(1):vdae142. PMID: 39233830
Primary central nervous system (CNS) tumors affect tens of thousands of patients each year, and there is a significant need for new treatments. Macrophage migration inhibitory factor (MIF) is a...
6.
Valdez C, Sanchez-Zuno G, Osmani L, Ibrahim W, Galan A, Bacchiocchi A, et al.
Oncotarget . 2024 Jul; 15:507-520. PMID: 39028303
Macrophage Migration Inhibitory Factor (MIF) and its homolog D-dopachrome Tautomerase (DDT) have been implicated as drivers of tumor progression across a variety of cancers. Recent evidence suggests MIF as a...
7.
Huang Y, Chen L, Li L, Qi Y, Tong H, Wu H, et al.
JCI Insight . 2024 Jul; 9(13). PMID: 38973609
Lipoprotein lipase (LPL) hydrolyzes circulating triglycerides (TGs), releasing fatty acids (FA) and promoting lipid storage in white adipose tissue (WAT). However, the mechanisms regulating adipose LPL and its relationship with...
8.
Yang H, Li J, Huang X, Bucala R, Xu A, Lan H
Front Immunol . 2024 Jun; 15:1361343. PMID: 38846956
Macrophages are a rich source of macrophage migration inhibitory factor (MIF). It is well established that macrophages and MIF play a pathogenic role in anti-glomerular basement membrane crescentic glomerulonephritis (anti-GBM...
9.
Li J, Leng L, Pantouris G, Manjula R, Piecychna M, Abriola L, et al.
J Biol Chem . 2024 Jun; 300(7):107443. PMID: 38838773
Functional variants of the gene for the cytokine macrophage migration inhibitory factor (MIF) are defined by a 4-nucleotide promoter microsatellite (-794 CATT, rs5844572) and confer risk for autoimmune, infectious, and...
10.
Valdez C, Sanchez-Zuno G, Bucala R, Tran T
Int J Mol Sci . 2024 May; 25(9). PMID: 38732068
Discovered as inflammatory cytokines, MIF and DDT exhibit widespread expression and have emerged as critical mediators in the response to infection, inflammation, and more recently, in cancer. In this comprehensive...