Richard B Sparks
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Explore the profile of Richard B Sparks including associated specialties, affiliations and a list of published articles.
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23
Citations
1190
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Recent Articles
1.
Hofman M, Tran B, Feldman D, Pokorska-Bocci A, Pichereau S, Wessen J, et al.
J Nucl Med
. 2024 Feb;
PMID: 38388517
[Ga]Ga-DPI-4452, a first-in-class carbonic anhydrase IX-binding radiolabeled peptide, is the imaging agent of a theranostic pair with [Lu]Lu-DPI-4452, developed for selecting and treating patients with carbonic anhydrase IX-expressing tumors. Here,...
2.
Yue E, Li Y, Douty B, He C, Mei S, Wayland B, et al.
ACS Med Chem Lett
. 2019 Nov;
10(11):1554-1560.
PMID: 31749910
A medicinal chemistry effort focused on identifying a structurally diverse candidate for phosphoinositide 3-kinase delta (PI3Kδ) led to the discovery of clinical candidate INCB050465 (, parsaclisib). The unique structure of...
3.
Smolarz K, Krause B, Graner F, Wagner F, Hultsch C, Bacher-Stier C, et al.
J Nucl Med
. 2013 Apr;
54(6):861-6.
PMID: 23568366
Unlabelled: The glutamic acid derivative (S)-4-(3-(18)F-Fluoropropyl)-l-glutamic acid ((18)F-FSPG, alias BAY 94-9392), a new PET tracer for the detection of malignant diseases, displayed promising results in non-small cell lung cancer patients....
4.
Liu X, Shin N, Koblish H, Yang G, Wang Q, Wang K, et al.
Blood
. 2010 Mar;
115(17):3520-30.
PMID: 20197554
Indoleamine 2,3-dioxygenase-1 (IDO1; IDO) mediates oxidative cleavage of tryptophan, an amino acid essential for cell proliferation and survival. IDO1 inhibition is proposed to have therapeutic potential in immunodeficiency-associated abnormalities, including...
5.
Koblish H, Hansbury M, Bowman K, Yang G, Neilan C, Haley P, et al.
Mol Cancer Ther
. 2010 Feb;
9(2):489-98.
PMID: 20124451
Malignant tumors arise, in part, because the immune system does not adequately recognize and destroy them. Expression of indoleamine-2,3-dioxygenase (IDO; IDO1), a rate-limiting enzyme in the catabolism of tryptophan into...
6.
Li J, Favata M, Kelley J, Caulder E, Thomas B, Wen X, et al.
Neoplasia
. 2010 Jan;
12(1):28-38.
PMID: 20072651
Cytokines in the bone marrow of multiple myeloma patients activate Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathways in tumor cells and promote tumor growth, survival, and...
7.
Liu P, Caulder E, Li J, Waeltz P, Margulis A, Wynn R, et al.
Clin Cancer Res
. 2009 Nov;
15(22):6891-900.
PMID: 19887489
Purpose: Deregulation of the Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway is a hallmark for the Philadelphia chromosome-negative myeloproliferative diseases polycythemia vera, essential thrombocythemia, and primary myelofibrosis. We...
8.
Siddiqui F, Barton K, Stricker H, Steyn P, LaRue S, Karvelis K, et al.
Hum Gene Ther
. 2007 Apr;
18(4):312-22.
PMID: 17408358
This study was done to aid in the design of a phase I gene therapy trial in patients with prostate cancer. We determined the dosimetric characteristics of our reporter gene...
9.
Sparks R, Polam P, Zhu W, Crawley M, Takvorian A, Mclaughlin E, et al.
Bioorg Med Chem Lett
. 2006 Nov;
17(3):736-40.
PMID: 17097290
Benzothiazole benzimidazole (S)-isothiazolidinone ((S)-IZD) derivatives 5 were discovered through a peptidomimetic modification of the tripeptide (S)-IZD protein tyrosine phosphatase 1B (PTP1B) inhibitor 1. These derivatives are potent, competitive, and reversible...
10.
Ala P, Gonneville L, Hillman M, Becker-Pasha M, Yue E, Douty B, et al.
J Biol Chem
. 2006 Oct;
281(49):38013-21.
PMID: 17028182
Structural analyses of the protein-tyrosine phosphatase 1B (PTP1B) active site and inhibitor complexes have aided in optimization of a peptide inhibitor containing the novel (S)-isothiazolidinone (IZD) phosphonate mimetic. Potency and...