Richard A Manderville
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Explore the profile of Richard A Manderville including associated specialties, affiliations and a list of published articles.
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90
Citations
874
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Recent Articles
1.
Zimmer K, Johnson R, Little H, Duhamel J, Manderville R
ACS Sens
. 2025 Feb;
PMID: 40008955
DNA aptamers can bind small molecule ligands with high affinity and specificity to produce a unique supramolecular structure. Methods to obtain structural information about the binding interaction coupled with sensitive...
2.
Chen Y, Johnson R, Manderville R, Liu J
Chem Res Toxicol
. 2025 Feb;
38(2):340-346.
PMID: 39910765
4-Aminobiphenyl (4-ABP) is a known human carcinogen that is implicated in the development of bladder cancers in smokers. The amine substituent undergoes bioactivation to generate nitrenium ions capable of covalently...
3.
Johnson R, Regan K, Manderville R
Bioconjug Chem
. 2025 Jan;
36(2):216-222.
PMID: 39838819
The ability to label synthetic oligonucleotides with fluorescent probes has greatly expanded their nanotechnological applications. To continue this expansion, it is essential to develop approachable, modular, and tunable fluorescent platforms....
4.
Johnson R, Pounder A, van der Zalm J, Chen A, Bell I, Van Raay T, et al.
Anal Chem
. 2024 Oct;
96(41):16252-16259.
PMID: 39360861
The construction of far-red fluorescent molecular rotors (FMRs) is an imperative task for developing nucleic acid stains that have superior compatibility with cellular systems and complex matrices. A typical strategy...
5.
Johnson R, Murray M, Roby D, Bycraft L, Churcher Z, Yadav S, et al.
ACS Sens
. 2023 Dec;
8(12):4756-4764.
PMID: 38063049
The ability of guanine (G)-rich DNA to bind toxic lead (Pb) ions within a G-quadruplex (GQ) motif is a leading DNA biosensor strategy. A major analytical hurdle for GQ detection...
6.
Johnson R, Murray M, Bycraft L, Myler P, Wetmore S, Manderville R
Bioconjug Chem
. 2023 Oct;
34(11):2066-2076.
PMID: 37857354
Interactions between DNA aptamers and protein targets hold promise for the development of pharmaceuticals and diagnostics. As such, the utilization of fluorescent nucleobase surrogates in studying aptamer-protein interactions is a...
7.
Regan K, Pounder A, Lin C, Chen L, Manderville R
J Phys Chem A
. 2023 Sep;
127(40):8365-8373.
PMID: 37773491
Aromatic chromophores possessing intramolecular hydrogen-bonds that can undergo excited-state intramolecular proton transfer (ESIPT) are critical tools for chemosensing/biosensing applications because they create large Stokes-shifted fluorescence with no overlap with the...
8.
Johnson R, Murray M, Bycraft L, Wetmore S, Manderville R
Chem Sci
. 2023 May;
14(18):4832-4844.
PMID: 37181758
Fluorescent molecular rotors (FMRs) are critical tools for probing nucleic acid structure and function. Many valuable FMRs have been incorporated into oligonucleotides, although the methods of doing so can be...
9.
Johnson R, van der Zalm J, Chen A, Bell I, Van Raay T, Al-Abdul-Wahid M, et al.
Anal Chem
. 2022 Jul;
94(31):11047-11054.
PMID: 35894588
The hemicyanine hybrid containing the 7-(diethylamino)coumarin (ACou) donor attached to the cationic indolenium (Ind) acceptor through a vinyl linkage (ACou-Ind) represents a classic ratiometric fluorescent probe for detecting nucleophilic analytes,...
10.
Van Riesen A, Le J, Slavkovic S, Churcher Z, Shoara A, Johnson P, et al.
ACS Appl Bio Mater
. 2022 Jan;
4(9):6732-6741.
PMID: 35006975
DNA three-way junctions (3WJs) consist of a Y-shaped hydrophobic branch point connecting three double-stranded stems and are viewed as druggable targets for cancer treatment. They are also important building blocks...