Ryan E Johnson
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Explore the profile of Ryan E Johnson including associated specialties, affiliations and a list of published articles.
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8
Citations
11
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Recent Articles
1.
Zimmer K, Johnson R, Little H, Duhamel J, Manderville R
ACS Sens
. 2025 Feb;
PMID: 40008955
DNA aptamers can bind small molecule ligands with high affinity and specificity to produce a unique supramolecular structure. Methods to obtain structural information about the binding interaction coupled with sensitive...
2.
Chen Y, Johnson R, Manderville R, Liu J
Chem Res Toxicol
. 2025 Feb;
38(2):340-346.
PMID: 39910765
4-Aminobiphenyl (4-ABP) is a known human carcinogen that is implicated in the development of bladder cancers in smokers. The amine substituent undergoes bioactivation to generate nitrenium ions capable of covalently...
3.
Johnson R, Regan K, Manderville R
Bioconjug Chem
. 2025 Jan;
36(2):216-222.
PMID: 39838819
The ability to label synthetic oligonucleotides with fluorescent probes has greatly expanded their nanotechnological applications. To continue this expansion, it is essential to develop approachable, modular, and tunable fluorescent platforms....
4.
Johnson R, Pounder A, van der Zalm J, Chen A, Bell I, Van Raay T, et al.
Anal Chem
. 2024 Oct;
96(41):16252-16259.
PMID: 39360861
The construction of far-red fluorescent molecular rotors (FMRs) is an imperative task for developing nucleic acid stains that have superior compatibility with cellular systems and complex matrices. A typical strategy...
5.
Johnson R, Murray M, Roby D, Bycraft L, Churcher Z, Yadav S, et al.
ACS Sens
. 2023 Dec;
8(12):4756-4764.
PMID: 38063049
The ability of guanine (G)-rich DNA to bind toxic lead (Pb) ions within a G-quadruplex (GQ) motif is a leading DNA biosensor strategy. A major analytical hurdle for GQ detection...
6.
Johnson R, Murray M, Bycraft L, Myler P, Wetmore S, Manderville R
Bioconjug Chem
. 2023 Oct;
34(11):2066-2076.
PMID: 37857354
Interactions between DNA aptamers and protein targets hold promise for the development of pharmaceuticals and diagnostics. As such, the utilization of fluorescent nucleobase surrogates in studying aptamer-protein interactions is a...
7.
Johnson K, Sharma A, Henry N, Wei M, Bie B, Hershberger C, et al.
Front Pain Res (Lausanne)
. 2023 May;
4:1139883.
PMID: 37251592
Taxanes, particularly paclitaxel and docetaxel, are chemotherapeutic agents commonly used to treat breast cancers. A frequent side effect is chemotherapy-induced peripheral neuropathy (CIPN) that occurs in up to 70% of...
8.
Johnson R, Murray M, Bycraft L, Wetmore S, Manderville R
Chem Sci
. 2023 May;
14(18):4832-4844.
PMID: 37181758
Fluorescent molecular rotors (FMRs) are critical tools for probing nucleic acid structure and function. Many valuable FMRs have been incorporated into oligonucleotides, although the methods of doing so can be...
9.
Johnson R, van der Zalm J, Chen A, Bell I, Van Raay T, Al-Abdul-Wahid M, et al.
Anal Chem
. 2022 Jul;
94(31):11047-11054.
PMID: 35894588
The hemicyanine hybrid containing the 7-(diethylamino)coumarin (ACou) donor attached to the cationic indolenium (Ind) acceptor through a vinyl linkage (ACou-Ind) represents a classic ratiometric fluorescent probe for detecting nucleophilic analytes,...
10.
Johnson R, Van Riesen A, Manderville R
Bioconjug Chem
. 2021 Sep;
32(10):2224-2232.
PMID: 34543022
We demonstrate the ability to distinguish Pb from K within the central cavity of the antiparallel G-quadruplex (GQ) DNA produced by the thrombin binding aptamer (TBA) using an internal molecular...