Richard A J Darby
Overview
Explore the profile of Richard A J Darby including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
14
Citations
157
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0
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Recent Articles
11.
Forde G, Ghose S, Slater N, Hine A, Darby R, Hitchcock A
Biotechnol Bioeng
. 2006 Apr;
95(1):67-75.
PMID: 16646090
Current approaches for purifying plasmids from bacterial production systems exploit the physiochemical properties of nucleic acids in non-specific capture systems. In this study, an affinity system for plasmid DNA (pDNA)...
12.
Darby R, Hine A
FASEB J
. 2005 Mar;
19(7):801-3.
PMID: 15760969
Affinity purification of plasmid DNA is an attractive option for the biomanufacture of therapeutic plasmids, which are strictly controlled for levels of host protein, DNA, RNA, and endotoxin. Plasmid vectors...
13.
Sollogoub M, Darby R, Cuenoud B, Brown T, Fox K
Biochemistry
. 2002 Jun;
41(23):7224-31.
PMID: 12044153
We have prepared oligonucleotides containing the novel base analogue 2'-aminoethoxy,5-propargylamino-U in place of thymidine and examined their ability to form intermolecular and intramolecular triple helices by DNase I footprinting and...
14.
Darby R, Sollogoub M, McKeen C, Brown L, Risitano A, Brown N, et al.
Nucleic Acids Res
. 2002 Apr;
30(9):e39.
PMID: 11972354
We have used oligonucleotides containing molecular beacons to determine melting profiles for intramolecular DNA duplexes, triplexes and quadruplexes (tetraplexes). The synthetic oligonucleotides used in these studies contain a fluorophore (fluorescein)...