Tom Brown
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Explore the profile of Tom Brown including associated specialties, affiliations and a list of published articles.
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279
Citations
3543
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Recent Articles
1.
Xiong B, Fioriti D, Neumann F, Riepin I, Brown T
Sci Data
. 2025 Feb;
12(1):277.
PMID: 39956804
This paper provides the background, methodology and validation for constructing a representation of the European high-voltage grid (AC lines from 220 to 750 kV and all DC lines) based on...
2.
Bein B, Chrysostomakis I, Arantes L, Brown T, Gerheim C, Schell T, et al.
Genome Biol
. 2025 Feb;
26(1):25.
PMID: 39930463
Museum collections harbor millions of samples, largely unutilized for long-read sequencing. Here, we use ethanol-preserved samples containing kilobase-sized DNA to show that amplification-free protocols can yield contiguous genome assemblies. Additionally,...
3.
Hampp J, Duren M, Brown T
PLoS One
. 2025 Jan;
20(1):e0314578.
PMID: 39854445
[This corrects the article DOI: 10.1371/journal.pone.0281380.].
4.
Mc Cartney A, Formenti G, Mouton A, De Panis D, Marins L, Leitao H, et al.
NPJ Biodivers
. 2024 Oct;
3(1):31.
PMID: 39407030
No abstract available.
5.
Dhara D, Hill A, Ramesh A, Wood M, El-Sagheer A, Brown T
J Am Chem Soc
. 2024 Oct;
146(43):29773-29781.
PMID: 39401255
Polyanionic antisense oligonucleotides hold great promise as RNA targeting drugs but issues with bioavailability hinder their development. Uncharged phosphorus-based backbones are promising alternatives but robust methods to produce them are...
6.
Bein B, Chrysostomakis I, Arantes L, Brown T, Gerheim C, Schell T, et al.
bioRxiv
. 2024 Oct;
PMID: 39386456
Museum collections harbor millions of samples, largely unutilized for long-read sequencing. Here, we use ethanol-preserved samples containing kilobase-sized DNA to show that amplification-free protocols can yield contiguous genome assemblies. Additionally,...
7.
Mc Cartney A, Formenti G, Mouton A, De Panis D, Marins L, Leitao H, et al.
NPJ Biodivers
. 2024 Sep;
3(1):28.
PMID: 39289538
A genomic database of all Earth's eukaryotic species could contribute to many scientific discoveries; however, only a tiny fraction of species have genomic information available. In 2018, scientists across the...
8.
Roddan R, Nathan W, Newman J, El-Sagheer A, Wilson D, Brown T, et al.
bioRxiv
. 2024 Sep;
PMID: 39282455
The SNM1A exonuclease plays a key role in repair of interstrand crosslinks (ICLs) which represent a particularly toxic class of DNA damage. Previous work suggests that the SWI/SNF family ATP-dependent,...
9.
Jin C, Li S, Vallis K, El-Sagheer A, Brown T
RSC Chem Biol
. 2024 Aug;
5(8):738-744.
PMID: 39092443
The reversible attachment of small molecules to oligonucleotides provides versatile tools for the development of improved oligonucleotide therapeutics. However, cleavable linkers in the oligonucleotide field are scarce, particularly with respect...
10.
Yi G, Ye M, Carrique L, El-Sagheer A, Brown T, Norbury C, et al.
Nat Struct Mol Biol
. 2024 Jul;
31(9):1426-1438.
PMID: 39054354
Tumor-suppressor let-7 pre-microRNAs (miRNAs) are regulated by terminal uridylyltransferases TUT7 and TUT4 that either promote let-7 maturation by adding a single uridine nucleotide to the pre-miRNA 3' end or mark...