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Riad Efendiev

Explore the profile of Riad Efendiev including associated specialties, affiliations and a list of published articles. Areas
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Articles 18
Citations 507
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Recent Articles
1.
Efendiev R, Bavencoffe A, Hu H, Zhu M, Dessauer C
J Biol Chem . 2012 Dec; 288(6):3929-37. PMID: 23264624
Scaffolding proteins often bring kinases together with their substrates to facilitate cell signaling. This arrangement is critical for the phosphorylation and regulation of the transient receptor potential vanilloid 1 (TRPV1)...
2.
Efendiev R, Dessauer C
J Cardiovasc Pharmacol . 2011 Oct; 58(4):339-44. PMID: 21978991
3'-5'-Cyclic adenosine monophosphate (cAMP), generated by adenylyl cyclase (AC), serves as a second messenger in signaling pathways regulating many aspects of cardiac physiology, including contraction rate and action potential duration,...
3.
Efendiev R, Samelson B, Nguyen B, Phatarpekar P, Baameur F, Scott J, et al.
J Biol Chem . 2010 Mar; 285(19):14450-8. PMID: 20231277
Spatiotemporal specificity of cAMP action is best explained by targeting protein kinase A (PKA) to its substrates by A-kinase-anchoring proteins (AKAPs). At synapses in the brain, AKAP79/150 incorporates PKA and...
4.
Kapiloff M, Piggott L, Sadana R, Li J, Heredia L, Henson E, et al.
J Biol Chem . 2009 Jul; 284(35):23540-6. PMID: 19574217
Protein kinase A-anchoring proteins (AKAPs) play important roles in the compartmentation of cAMP signaling, anchoring protein kinase A (PKA) to specific cellular organelles and serving as scaffolds that assemble localized...
5.
Cinelli A, Efendiev R, Pedemonte C
Am J Physiol Renal Physiol . 2008 Aug; 295(4):F1117-25. PMID: 18701625
Most of the transepithelial transport of sodium in proximal tubules occurs through the coordinated action of the apical sodium/proton exchanger and the basolateral Na-K-ATPase. Hormones that regulate proximal tubule sodium...
6.
Efendiev R, Budu C, Bertorello A, Pedemonte C
J Biol Chem . 2008 Apr; 283(25):17561-7. PMID: 18420589
Motion of integral membrane proteins to the plasma membrane in response to G-protein-coupled receptor signals requires selective cargo recognition motifs that bind adaptor protein 1 and clathrin. Angiotensin II, through...
7.
Efendiev R, Cinelli A, Leibiger I, Bertorello A, Pedemonte C
FEBS Lett . 2006 Sep; 580(21):5067-70. PMID: 16949583
Dopamine is a major regulator of sodium reabsorption in proximal tubule epithelia. It induces the endocytosis of plasma membrane Na,K-ATPase molecules, and this results in a reduced capacity of the...
8.
Chen Z, Krmar R, Dada L, Efendiev R, Leibiger I, Pedemonte C, et al.
Am J Respir Cell Mol Biol . 2006 Feb; 35(1):127-32. PMID: 16498080
Activation of G protein-coupled receptor by dopamine and hypoxia-generated reactive oxygen species promote Na+,K+-ATPase endocytosis. This effect is clathrin dependent and involves the activation of protein kinase C (PKC)-zeta and...
9.
Efendiev R, Pedemonte C
J Am Soc Nephrol . 2005 Dec; 17(1):31-8. PMID: 16338965
Renal sodium homeostasis is a major determinant of BP and is regulated by several natriuretic and antinatriuretic hormones. These hormones, acting through intracellular secondary messengers, either activate or inhibit proximal...
10.
Pedemonte C, Efendiev R, Bertorello A
Semin Nephrol . 2005 Sep; 25(5):322-7. PMID: 16139687
In the current report we review the results that lay grounds for the model of intracellular sodium-mediated dopamine-induced endocytosis of Na,K-ATPase. Under conditions of a high salt diet, dopamine activates...